Comparison of the efficacies of three fluoroquinolone antimicrobial agents, given as continuous or pulsed-water medication, against Escherichia coli infection in chickens
Comparison of the efficacies of three fluoroquinolone antimicrobial agents, given as continuous or pulsed-water medication, against Escherichia coli infection in chickens
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DOI：
10.1128/aac.42.1.83
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发表时间：
1998-01-01
影响因子：
4.9
通讯作者：
Froyman, R
中科院分区：
文献类型：
--
作者：
Charleston, B;Gate, JJ;Froyman, R
本研究采用感染性支气管炎病毒-大肠杆菌大肠杆菌血症模型，比较了连续或脉冲水给药与恩诺沙星、达诺沙星和萨拉沙星在8组90只鸡中的疗效。该模型产生了严重大肠杆菌血症鸟类的典型病变；未给药的感染鸟死亡率为43.5%，发病率为89%，17.8%的鸟有严重病变，平均气囊病变评分为2.58分。实验表明连续给药和脉冲给药在临床上是等效的。然而，在所研究的所有氟喹诺酮类药物中，与接受脉冲剂量的鸟类相比，持续给药的鸟类死亡率更低，病情也更轻。与未给药的感染对照相比，只有持续给药的鸟类发病率显著降低（32%）。仅给予恩诺沙星和danoflo沙星（连续和脉冲治疗）的鸟类死亡率显著低于对照组（分别为6.7和11.0%，16.8和19.2%），仅给予恩诺沙星和danoflo沙星连续和脉冲治疗的鸟类发生严重病变的比例显著低于对照组（连续和脉冲治疗的鸟类分别为2.2和6.7%）。除使用萨拉沙星脉冲水治疗外，使用三种氟喹诺酮类药物（连续和脉冲治疗）中的任何一种治疗的鸟类，与未使用药物的鸟类相比，其平均气囊损伤评分显著降低（接受恩诺沙星、达诺沙星和萨拉沙星连续和脉冲治疗的鸟类的气囊损伤评分分别为0.60和0.83,1.38和1.63,1.80和2.05）。与未感染的鸡相比，存活或接受药物治疗后恢复的鸡的性能没有受到影响，恩诺沙星比在饮用水中给药治疗大肠杆菌血症的鸡更有效，同样，在治疗大肠杆菌血症方面，丹诺沙星似乎比萨拉沙星更有效。
This study compared the efficacy of continuous or pulsed-water medication with enrofloxacin, danofloxacin, and sarafloxacin in eight groups of 90 chicks each by using an infectious bronchitis virus-Escherichia coli model of colisepticemia. The model produced lesions of typical those occurring in birds with severe colisepticemia; for the infected, nonmedicated birds the mortality was 43.5% and the morbidity was 89%, 17.8% of birds had severe lesions, and the birds had a mean air sac lesion score of 2.58, This experiment showed that continuous dosing and pulsed dosing are clinically equivalent. However, for all fluoroquinolones studied, there was a trend for the continuously mediated birds to have lower mortality and less severe disease than birds receiving pulsed doses, Compared with infected, nonmedicated controls, only birds continuously medicated with enrofloxacin had a significantly lower morbidity (32%), and only birds medicated with enrofloxacin and danofloxacin (continuous and pulsed treatments) had significantly lower mortality (6.7 and 11.0% and 16.8 and 19.2% for continuous and pulsed treatments with enrofloxacin and danofloxacin, respectively), A significantly lower proportion of birds only in the groups medicated with enrofloxacin had severe lesions (for birds receiving continuous and pulsed treatments, 2.2 and 6.7%, respectively), Birds medicated with any of the three fluoroquinolones (continuous and pulsed treatments) except pulsed-water treatment with sarafloxacin had significantly reduced mean air sac lesion scores compared with the scores for nonmedicated birds (air sac lesion scores, 0.60 and 0.83, 1.38 and 1.63, and 1.80 and 2.05 for birds receiving continuous and pulsed treatments with enrofloxacin, danofloxacin, and sarafloxacin, respectively), The performance of the birds that survived the challenge or that recovered after receiving medication was not compromised compared to the performance of noninfected birds, Enrofloxacin was more efficacious than either danofloxacin or sarafloxacin for the treatment of colisepticemia in chickens by medication in drinking water, Similarly, danofloxacin appeared to be more effective than sarafloxacin in treating colisepticemia.