Novel findings: Expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in thoracic aortic dissection and aneurysm
Novel findings: Expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in thoracic aortic dissection and aneurysm
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DOI：
10.1177/1470320314549219
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发表时间：
2015-12-01
影响因子：
2.9
通讯作者：
Zhang, Er-yong
中科院分区：
文献类型：
--
作者：
Li, Yang;Hu, Jia;Zhang, Er-yong
简介：血管紧张素转换酶（ACE）和ACE 2是肾素-血管紧张素系统的重要调节因子，参与了一系列心血管疾病的发生发展。材料与方法：我们测定了73例急性胸主动脉夹层（n=34），动脉瘤（n=18），冠心病（n=21）和13名健康志愿者的ACE血浆浓度。结果：急性主动脉夹层患者血浆ACE浓度及主动脉组织ACE mRNA水平均明显低于动脉瘤患者、冠心病患者及健康对照组。夹层组织中ACE 2基因表达水平明显低于动脉瘤组织（8.0 ± 17.44，p
Introduction: Angiotensin-converting enzyme (ACE) and ACE2 are key regulators of the renin-angiotensin system, which has been shown to participate in a series of cardiovascular diseases. We hypothesized that dysregulated gene expression of ACE and ACE2 contribute to the formation of thoracic aortic dissection and aneurysm.Materials and methods: We assessed ACE plasma concentration in 73 patients with acute thoracic aortic dissection (n=34), aneurysm (n=18), coronary heart disease (n=21) and 13 healthy volunteers. ACE and ACE2 gene expression in available aortic tissues was also examined by using quantitative real-time polymerase chain reaction.Results: In patients with acute aortic dissection, ACE plasma concentration and its mRNA level in aortic tissue were markedly reduced compared with those in patients with aneurysm, coronary heart disease and healthy controls. The level of ACE2 gene expression in dissection samples was also significantly lower than that in aneurysm (8.017.44, p