The Catalytic Asymmetric Mukaiyama-Michael Reaction of Silyl Ketene Acetals with α,β-Unsaturated Methyl Esters
The Catalytic Asymmetric Mukaiyama-Michael Reaction of Silyl Ketene Acetals with α,β-Unsaturated Methyl Esters
复制标题
DOI：
10.1002/anie.201712088
复制
发表时间：
2018-02-23
影响因子：
16.6
通讯作者：
List, Benjamin
中科院分区：
文献类型：
--
作者：
Gatzenmeier, Tim;Kaib, Philip S. J.;List, Benjamin
α，β-不饱和酯是容易获得的，但在不对称催化中活化具有挑战性的底物。我们现在描述了甲硅烷基烯酮缩醛与α，β-不饱和甲酯的高效、通用和高对映选择性的Mukaiyama-Michael反应，该反应由甲硅烷基亚胺基二磷酰亚胺（IDPi）刘易斯酸催化。
alpha,beta-Unsaturated esters are readily available but challenging substrates to activate in asymmetric catalysis. We now describe an efficient, general, and highly enantioselective Mukaiyama-Michael reaction of silyl ketene acetals with alpha,beta-unsaturated methyl esters that is catalyzed by a silylium imidodiphosphorimidate (IDPi) Lewis acid.