Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage
Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage
复制标题
氨溴索通过抑制脑出血后小胶质细胞内质网应激来改善神经元存活并减少白质损伤
DOI：
10.1155/2020/8131286
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发表时间：
2020-03-28
影响因子：
--
通讯作者：
Yu, Anyong
中科院分区：
文献类型：
--
作者：
Jiang, Xuheng;Zhang, Ji;Yu, Anyong
脑出血已成为严重的公共卫生问题。肺炎发生在所有ICH患者的43%中，是严重影响结局的常见并发症，占ICH患者总死亡率的1/3以上。氨溴索可能是ICH合并肺炎患者的有效辅助治疗。但其对脑出血后功能恢复的影响及其可能机制尚不清楚。在本研究中，结果表明，35 mg/kg和70 mg/kg氨溴索通过减轻小胶质细胞活化和减少促炎细胞因子蓄积，促进ICH小鼠神经元存活并减少白色纤维束损伤。其机制可能与抑制内质网应激有关，包括IRE 1 α/TRAF 2信号通路，为脑出血的治疗开辟了新的途径，也为氨溴索的临床应用打开了新的窗口。
Intracerebral hemorrhage (ICH) has been becoming a serious public health problem. Pneumonia, occurring in 43% of all ICH patients, is a common complication heavily influencing outcome and accounting for more than 1/3 of the overall mortality in patients with ICH. Ambroxol may be an effective additional treatment for ICH patients with pneumonia. But its effect and potential mechanism on functional recovery post-ICH still remain elusive. In the present study, the results indicated that 35 mg/kg and 70 mg/kg ambroxol facilitated neuronal survival and reduced white matter fiber bundle damage due to mitigating microglial activation and reducing proinflammatory cytokine accumulation in mice with ICH. The possible mechanism might be due to suppressing endoplasmic reticulum stress involving the IRE1α/TRAF2 signaling pathway, which paves a new path for the treatment of ICH and opens a new window for the use of ambroxol in clinical practice.