Diversity of bilateral synaptic assemblies for binaural computation in midbrain single neurons
Diversity of bilateral synaptic assemblies for binaural computation in midbrain single neurons
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DOI：
10.1016/j.heares.2017.09.007
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发表时间：
2017-11-01
期刊：
影响因子：
2.8
通讯作者：
Yan, Jun
中科院分区：
文献类型：
--
作者：
He, Na;Kong, Lingzhi;Yan, Jun
双耳听觉赋予了许多有益的功能，但我们对其潜在神经基质的理解是有限的。本研究探讨听觉中脑下丘中央核（ICc）的双侧突触组装和双耳计算（或整合）。采用在体全细胞膜片钳技术，记录单个ICc神经元对对侧、同侧和双侧刺激的兴奋性和抑制性突触后电位（EPSPs/IPSPs）。根据对侧和同侧的EPSP/IPSP，共鉴定出7种类型的突触。这些包括EPSP-EPSP（EE）、E-IPSP（El）、E-no response（EO）、II、IE、10和复合模式（CM）神经元。CM神经元对侧或同侧刺激表现出频率和/或幅度依赖性的EPSP/IPSP。双侧刺激诱发的EPSP/IPSP可能大于（易化）、类似于（无效）或小于（抑制）对侧刺激诱发的EPSP/IPSP。我们的研究结果使我们的小组能够描述中脑双耳计算的新神经回路。(C)2017爱思唯尔B. V.保留所有权利。
Binaural hearing confers many beneficial functions but our understanding of its underlying neural substrates is limited. This study examines the bilateral synaptic assemblies and binaural computation (or integration) in the central nucleus of the inferior colliculus (ICc) of the auditory midbrain, a key convergent center. Using in-vivo whole-cell patch-clamp, the excitatory and inhibitory postsynaptic potentials (EPSPs/IPSPs) of single ICc neurons to contralateral, ipsilateral and bilateral stimulation were recorded. According to the contralateral and ipsilateral EPSP/IPSP, 7 types of bilateral synaptic assemblies were identified. These include EPSP-EPSP (EE), E-IPSP (El), E-no response (EO), II, IE, 10 and complex mode (CM) neurons. The CM neurons showed frequency- and/or amplitude-dependent EPSPs/IPSPs to contralateral or ipsilateral stimulation. Bilateral stimulation induced EPSPs/IPSPs that could be larger than (facilitation), similar to (ineffectiveness) or smaller than (suppression) those induced by contra lateral stimulation. Our findings have allowed our group to characterize novel neural circuitry for binaural computation in the midbrain. (C) 2017 Elsevier B.V. All rights reserved.