microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis.
microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis.
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DOI：
10.1007/978-3-319-22380-3_4
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发表时间：
2015
影响因子：
--
通讯作者：
Santulli G
中科院分区：
文献类型：
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作者：
Santulli G
内皮细胞（EC）和血管平滑肌细胞（VSMC）是血管系统中的主要细胞类型。我们在这里描述了如何microRNAs（miRs）-非编码RNA，可以通过翻译抑制和/或转录后降解调节基因表达的独特调节EC和VSMC的功能，在生理和疾病。特别是，深入探讨了分别调节EC和VSMC功能的主要调节因子miR-126和miR-143/145的具体作用。我们还描述了miR在关键心血管过程（包括血管生成、动脉粥样硬化和血管成形术后支架内再狭窄）的病理生理学调节中的机制作用。目前可用的治疗方案的缺点进行了讨论，指出的挑战和潜在的临床机会提供基于miR的治疗。
Endothelial cells (EC) and vascular smooth muscle cells (VSMC) are the main cell types within the vasculature. We describe here how microRNAs (miRs)—noncoding RNAs that can regulate gene expression via translational repression and/or post-transcriptional degradation—distinctively modulate EC and VSMC function in physiology and disease. In particular, the specific roles of miR-126 and miR-143/145, master regulators of EC and VSMC function, respectively, are deeply explored. We also describe the mechanistic role of miRs in the regulation of the pathophysiology of key cardiovascular processes including angiogenesis, atherosclerosis, and in-stent restenosis post-angioplasty. Drawbacks of currently available therapeutic options are discussed, pointing at the challenges and potential clinical opportunities provided by miR-based treatments.