Solvent-free Pd-catalysed N-arylation of amines, amides and diaza-18-crown-6
Solvent-free Pd-catalysed N-arylation of amines, amides and diaza-18-crown-6
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DOI：
10.1070/mc2003v013n04abeh001753
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发表时间：
2003-07-01
影响因子：
1.9
通讯作者：
Beletskaya, IP
中科院分区：
文献类型：
--
作者：
Artamkina, GA;Ermolina, MV;Beletskaya, IP
(PdL)-L-0和CuI/1，2-二(甲氨基)环己烷催化的胺、酰胺和二氮-18-冠-6与弱活化的芳基溴化物的N-芳基化反应和CuI/1，2-二(甲氨基)环己烷催化的吡咯烷酮-2与2-溴噻吩的芳基化反应，均可在60-100℃无溶剂条件下进行，芳基化产物产率较高(60-78%)。
The N-arylation of amines, amides and diaza-18-crown-6 with-weakly activated aryl bromides catalysed by (PdL)-L-0 and the arylation of pyrrolidone-2 with 2-bromothiophene catalysed by CuI/1,2-di(methylamino)cyclohexane can be performed in the presence of graphite at 60-100degreesC without solvent to give arylation products in good yields (60-78%).