Topographical projection from the hippocampal formation to the amygdala: A combined anterograde and retrograde tracing study in the rat
Topographical projection from the hippocampal formation to the amygdala: A combined anterograde and retrograde tracing study in the rat
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DOI：
10.1002/cne.20919
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发表时间：
2006-05-20
影响因子：
2.5
通讯作者：
Yasui, Y
中科院分区：
文献类型：
--
作者：
Kishi, T;Tsumori, T;Yasui, Y
海马体和杏仁核负责调节情绪、学习和行为。海马区向杏仁核的投射已被证明起源于大鼠杏仁角区CA1区(Sub/CA1)的下丘脑及其邻近部分，然而，这一通路的地形图组织仍未得到充分研究。为了明确这一点，我们分别对大鼠进行了生物素化葡聚糖胺(BDA)和霍乱毒素B亚单位(CTB)的顺行和逆行示踪。一系列的BDA实验表明，杏仁核的内侧至外侧终止轴是由颞叶至间隔的起始轴决定的。简而言之，Sub/CA1的颞区优先投射到杏仁内侧区，包括内侧核、间质核、基底内侧核和杏仁-海马区，并逐渐将更多的Sub/CA1隔部分的传出分布在杏仁核的更外侧区域。杏仁中央核内分布的亚/CA1纤维较少。CTB逆行追踪证实了这一地形图，并显示杏仁核中央核的少量海马神经支配。这些观察表明，沿着海马轴排列的不同的Sub/CA1区域可能会影响杏仁核功能的不同模式。
The hippocampal formation and amygdala are responsible for regulating emotion, learning, and behavior. The hippocampal projection to the amygdala has been demonstrated to originate in the subiculum and adjacent portion of field CA1 of the Ammon's horn (Sub/CA1) in the rat; however, the topographical organization of this pathway is still understudied. To make it clear, we performed anterograde and retrograde tracing with biotinylated dextran amine (BDA) and cholera toxin B subunit (CTb), respectively, in the rat. A series of BDA experiments revealed that the temporal-to-septal axis of origin determined a medial-to-lateral axis of termination in the amygdala. Briefly, the temporal region of the Sub/CA1 projects preferentially to the medial amygdaloid region including the medial, intercalated, and basomedial nuclei and the amygdalohippocampal transition area, and progressively more septal portions of the Sub/CA1 distribute their efferents in more lateral regions of the amygdala. Sub/CA1 fibers distributed in the central amygdaloid nucleus were relatively few. Retrograde tracing with CTb confirmed this topography and revealed little hippocampal innervation of the central nucleus of the amygdala. These observations suggest that distinct Sub/CA1 regions arranged along the longitudinal hippocampal axis may influence distinct modalities of the amygdala function.