Cytoplasmic accumulation of α-catenin is associated with aggressive features in laryngeal squamous-cell carcinoma
Cytoplasmic accumulation of α-catenin is associated with aggressive features in laryngeal squamous-cell carcinoma
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DOI：
10.1002/(sici)1097-0215(19981023)79:5
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发表时间：
1998-10-23
影响因子：
6.4
通讯作者：
Kosma, VM
中科院分区：
文献类型：
--
作者：
Hirvikoski, P;Kumpulainen, EJ;Kosma, VM
Aberrations in the function of alpha-catenin (alpha-cat), the anchoring protein of E-cadherin, are believed to cause dysfunction of the cadherin-catenin complex, leading to disturbed cell-cell adhesion. It has been suggested that expression of alpha-cat in human tumours might be a better indicator of aggressive phenotype than expression of E-cadherin. The value of alpha-cat as a prognostic marker in laryngeal squamous cell carcinoma (LSCC) is unclear. To determine the potential prognostic significance of alpha-cat, paraffin-embedded samples from 159 patients with invasive carcinoma left in the section and with long-term follow-up were evaluated immuno-histochemically for alpha-cat expression, and the results were related to histopathological grade, tumour stage and survival. Two patterns of staining were observed: pure membranous staining (57%) and membranous staining with cytoplasmic involvement (43%). Cytoplasmic involvement of alpha-cat was associated with dedifferentiation, advanced tumour stage and nodal status. In addition, supra-glottic tumours showed more often cytoplasmic involvement of alpha-cat than glottic tumours. Patients with cytoplasmic involvement appeared to have a trend towards poor overall survival, though without statistical significance. These results suggest that cytoplasmic involvement of alpha-cat is associated with aggressive behaviour and metastatic phenotype of LSCC. Int. J. Cancer (Pred. Oncol.) 79:546-550, 1998. (C) 1998 Wiley-Liss, Inc.
