Cognitive function, health-related quality of life, and symptoms of depression and anxiety sensitivity are impaired in patients with the postural orthostatic tachycardia syndrome (POTS)
Cognitive function, health-related quality of life, and symptoms of depression and anxiety sensitivity are impaired in patients with the postural orthostatic tachycardia syndrome (POTS)
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DOI：
10.3389/fphys.2014.00230
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发表时间：
2014-06-25
影响因子：
4
通讯作者：
Lambert, Gavin W.
中科院分区：
文献类型：
--
作者：
Anderson, Jake W.;Lambert, Elisabeth A.;Lambert, Gavin W.
体位性直立性心动过速综合征(POTS)是一种当个体处于直立位置时心率异常增加的情况。除了明显的心动过速、晕厥和晕厥外，POTS患者还经常抱怨头晕、疲劳和注意力难以集中。本研究评估了POTS患者的精神共病、焦虑敏感性和与健康相关的生活质量，并检查了一般认知能力。资料来源于POTS患者(n=15，女性12例，年龄30~3岁)和年龄匹配的健康人(n=30，女性21例，年龄32~2岁)。患有POTS的患者通常表现为抑郁、焦虑升高和焦虑敏感度增加，特别是在心脏症状方面，并且在生理和精神健康领域的健康相关生活质量较差。虽然POTS患者在当前智力功能测试(语言和非语言10)以及集中注意力(数字前移)和短期记忆(数字后移)方面表现较差，但测试结果在很大程度上受到多年教育以及潜在的抑郁和焦虑水平的影响。在POTS患者中，对头部向上倾斜做出反应的认知表现的急剧变化是明显的。从研究结果可以得出结论，患有POTS的参与者有更多的抑郁和更高水平的焦虑。这些潜在的症状影响了POTS患者的认知，特别是在注意力和短期记忆的认知领域。我们的结果表明，心理干预可能有助于POTS患者的康复，并促进对其他治疗方式的吸收和坚持。
The Postural Orthostatic Tachycardia Syndrome (POTS) is a condition in which heart rate increases abnormally when the individual assumes an upright position. In addition to the marked tachycardia, presyncope, and syncope, patients with POTS often complain of light-headedness, fatigue, and difficulty in concentrating. The present study assessed individuals with POTS for psychiatric comorbidity, anxiety sensitivity and health related quality of life and examined general cognitive ability. Data was obtained from patients with POTS (n = 15, 12 female, aged 30 3 years) and age matched healthy subjects (n = 30, 21 female, aged 32 2 years). Patients with POTS commonly presented with symptoms of depression, elevated anxiety and increased anxiety sensitivity, particularly with regards to cardiac symptoms, and had a poorer health related quality of life in both the physical and mental health domains. While patients with POTS performed worse in tests of current intellectual functioning (verbal and non-verbal 10) and in measures of focused attention (digits forward) and short term memory (digits back), test results were influenced largely by years of education and the underlying level of depression and anxiety. Acute changes in cognitive performance in response to head up tilt were evident in the POTS patients. From results obtained, it was concluded that participants with POTS have an increased prevalence of depression and higher levels of anxiety. These underlying symptoms impact on cognition in patients with POTS, particularly in the cognitive domains of attention and short-term memory. Our results indicate that psychological interventions may aid in recovery and facilitate uptake and adherence of other treatment modalities in patients with POTS.