Acupuncture/electroacupuncture enhances anti-depressant effect of Seroxat: the Symptom Checklist-90 scores.
Acupuncture/electroacupuncture enhances anti-depressant effect of Seroxat: the Symptom Checklist-90 scores.
复制标题
DOI：
10.4103/1673-5374.125353
复制
发表时间：
2014-01-15
影响因子：
6.1
通讯作者：
Xiao W
中科院分区：
文献类型：
--
作者：
Chen J;Lin W;Wang S;Wang C;Li G;Qu S;Huang Y;Zhang Z;Xiao W
将105例原发性单相抑郁症患者随机分为3组：药物组（服用赛乐特）、针刺组（赛乐特+针刺）和电针组（赛乐特+针刺+电针）。在干预前和治疗2、4、6和10周后，使用心理测量问卷（症状自评量表-90）评估患者的症状。随着治疗的进展，三组患者的症状自评量表（Symptom Checklist-90）的各个因子评分和总分均降低。针刺组和电针组的总分及强迫症状、抑郁、焦虑因子分均显著低于药物组。针刺组与电针组在各因子分及总分上均无显著性差异。电针组10周时的躯体化、抑郁、敌对和恐怖焦虑等因子评分较电针治疗6周后的相应评分有所增加。我们的研究结果表明，单用赛乐特或与针灸/电针联合使用，可以对原发性单相抑郁症患者产生显着的效果。此外，针灸/电针具有快速起效的治疗效果，并对强迫症、抑郁症和焦虑症症状产生显著改善。
One hundred and five patients with primary unipolar depression were randomly divided into three groups: drug group (Seroxat administration), acupuncture group (Seroxat plus acupuncture), and electroacupuncture group (Seroxat plus acupuncture plus electroacupuncture). Patients’ symptoms were evaluated using a psychometric questionnaire, the Symptom Checklist-90, before intervention and after 2, 4, 6 and 10 weeks of treatment. The individual factor scores and the total score from the Symptom Checklist-90 reduced in all three groups as treatment progressed. In the acupuncture and electroacupuncture groups, the total score and the factor scores for obsessive-compulsive symptoms, depression, and anxiety were significantly lower than those in the drug group. There was no significant difference in the factor scores or total scores between the acupuncture and electroacupuncture groups. Some factor scores in the electroacupuncture group, such as somatization, depression, hostility, and phobic anxiety, were increased at 10 weeks compared with the respective score immediately after the course of electroacupuncture at 6 weeks. Our findings indicate that administration of Seroxat alone or in combination with acupuncture/electroacupuncture can produce a significant effect in patients with primary unipolar depression. Furthermore, acupuncture/electroacupuncture has a rapid onset of therapeutic effect and produces a noticeable improvement in obsessive-compulsive, depressive and anxiety symptoms.