Paris polyphylla: Chemical and Biological Prospectives
Paris polyphylla: Chemical and Biological Prospectives
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DOI：
10.2174/1871520614666140611101040
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发表时间：
2014-01-01
影响因子：
2.8
通讯作者：
Singh, Narayan
中科院分区：
文献类型：
--
作者：
Negi, Jagmohan S.;Bisht, Vinod K.;Singh, Narayan
巴黎史密斯被广泛用于印度和中国的传统药物系统，主要是因为它的抗癌特性。国内和国际对Polyphylla的需求不断增加，大部分供应来自野生。非法和不科学的开发加上栖息地的破坏减少了该物种的自然种群，因此该物种属于脆弱类别。恢复和保护这种潜在的草本植物的自然种群是先决条件。本文就其化学成分和生物活性的研究进展作一综述。已从多叶重楼中分离出次级代谢物，如胡萝卜苷、多叶重楼苷D、β-蜕皮甾酮、巴黎皂苷I、II、V、VI、VII、H、薯蓣皂苷、寡糖、七糖、八糖、胡卢巴皂苷A、原纤细青霉素、巴黎云那皂苷G-J、Padelaoside B、pinnatasterone、formosanin C和20-羟基蜕皮皂苷。还报道了几种生物活性，如抗癌、抗肿瘤、细胞毒性、驱虫、抗微生物、抗血管生成、免疫刺激、收缩和止血。因此，本文的综述将有助于研究者和科学家进行进一步的研究。
Paris polyphylla J.E. Smith is extensively used in traditional systems of Indian and Chinese medicines mainly for its anticancerous property. The national and international demand for P. polyphylla is constantly increasing and most of the supplies come from wild. Illegal and unscientific exploitation coupled with habitat destruction decreases the natural population of the herb, as a consequence this species comes under vulnerable category. Restoration and conservation of the natural population of this potential herb is prerequisites. This article aims to provide an overview on chemical and biological prospective of P. polyphylla. Secondary metabolites such as daucosterol, polyphyllin D, beta -ecdysterone, Paris saponins I, II, V, VI, VII, H, dioscin, oligosaccharides, heptasaccharide, octasaccharide, trigofoenoside A, protogracillin, Paris yunnanosides G-J, padelaoside B, pinnatasterone, formosanin C and 20-hydroxyecdyson saponins have been isolated from P. polyphylla. Several biological activities such as anticancerous, antitumor, cytotoxic, anthelmintic, antimicrobial, antiangiogenic, immunostimulating, contractile and hemostatic have also been reported. Consequently, this review will be helpful to the researcher and scientist for further research.