Cardiac Risk and Disordered Eating: Decreased R Wave Amplitude in Women with Bulimia Nervosa and Women with Subclinical Binge/Purge Symptoms
Cardiac Risk and Disordered Eating: Decreased R Wave Amplitude in Women with Bulimia Nervosa and Women with Subclinical Binge/Purge Symptoms
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DOI：
10.1002/erv.2463
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发表时间：
2016-11-01
影响因子：
5.3
通讯作者：
Thorne, Tyler
中科院分区：
文献类型：
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作者：
Green, Melinda;Rogers, Jennifer;Thorne, Tyler
本研究的目的有三个方面。首先，我们检查了患有神经性暴食症的女性(n=12)和有阈值以下暴饮暴食/泻下症状的女性(n=20)，与没有症状的女性(n=20)相比，心电图上的平均R波振幅是否降低，这是心脏风险的一个指标。第二，我们考察了这个标记是否在实验范式中普遍存在，包括在同情性挑战任务之前和之后。第三，我们调查了这一标记物的行为预测因素，包括暴饮暴食频率和按亚型(饮食限制、过度运动、自我诱导呕吐和泻药滥用)评估的通便频率。3(ED症状状态)x 5(实验条件)混合因素方差分析(协变量：体重指数、年龄)的结果表明，与无症状的女性相比，患有神经性暴食症和亚临床暴饮暴泻症状的女性的平均R波振幅显著降低；这种影响在实验条件下普遍存在。多元回归分析显示，在所有实验条件下，狂饮和通便行为，尤其是泻药滥用作为通便方法，预示着R波幅度的下降。版权所有(C)2016 John Wiley&Sons，Ltd和饮食失调协会。
The purpose of the present study was threefold. First, we examined whether women with bulimia nervosa (n=12) and women with subthreshold binge/purge symptoms (n=20) showed decreased mean R wave amplitude, an indicator of cardiac risk, on electrocardiograph compared to asymptomatic women (n=20). Second, we examined whether this marker was pervasive across experimental paradigms, including before and after sympathetic challenge tasks. Third, we investigated behavioural predictors of this marker, including binge frequency and purge frequency assessed by subtype (dietary restriction, excessive exercise, self-induced vomiting, and laxative abuse). Results of a 3 (ED symptom status) x 5 (experimental condition) mixed factorial ANCOVA (covariates: body mass index, age) indicated women with bulimia nervosa and women with subclinical binge/purge symptoms demonstrated significantly reduced mean R wave amplitude compared to asymptomatic women; this effect was pervasive across experimental conditions. Multiple regression analyses showed binge and purge behaviours, most notably laxative abuse as a purge method, predicted decreased R wave amplitude across all experimental conditions. Copyright (c) 2016 John Wiley & Sons, Ltd and Eating Disorders Association.