Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores.
Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores.
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DOI：
10.1039/c6ob01199c
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发表时间：
2016-07-06
影响因子：
3.2
通讯作者：
Kool ET
中科院分区：
文献类型：
--
作者：
Kölmel DK;Barandun LJ;Kool ET
本文提出了一种简便、通用的制备含不同荧光基团的炔基C-核苷的方法。以Sonogashira偶联反应为关键反应，将染料偶联为易得的乙炔功能化脱氧核糖衍生物。新的C-核苷被用于制备基于DNA的多荧光团。提出了用不同的荧光团取代DNA碱基制备核苷的一般合成路线。
A facile and general procedure for the preparation of alkynyl C-nucleosides with varied fluorophores is presented. Sonogashira coupling was used as a key reaction to conjugate the dyes to an easily accessible ethynyl functionalized deoxyribose derivative. The new C-nucleosides were used for the preparation of DNA-based polyfluorophores. A general synthetic route for the facile preparation of nucleosides with varied fluorophores replacing a DNA base is presented.