Causes of death in long-term survivors of head and neck cancer.
Causes of death in long-term survivors of head and neck cancer.
复制标题
DOI：
10.1002/cncr.28588
复制
发表时间：
2014-05-15
期刊：
影响因子：
6.2
通讯作者：
Elkin, Elena B.
中科院分区：
文献类型：
--
作者：
Baxi, Shrujal S.;Pinheiro, Laura C.;Patil, Sujata M.;Pfister, David G.;Oeffinger, Kevin C.;Elkin, Elena B.
头颈鳞状细胞癌 (HNSCC) 的幸存者面临多种原因造成的过高死亡率。我们使用基于人群的监测、流行病学和最终结果 (SEER) 癌症登记数据来评估 1992 年至 2005 年间诊断出的非转移性 HNSCC 患者的死因，这些患者在诊断后存活了至少三年（长期幸存者）。我们使用竞争风险比例风险回归来估计以下原因导致的死亡概率：HNSCC、不包括 HNSCC 的第二原发恶性肿瘤 (SPM)、心血管疾病 (CVD) 和其他原因。我们确定了 35,958 名 HNSCC 3 年幸存者，诊断时的中位年龄为 60 岁（范围为 18 至 100 岁），中位随访时间为 7.7 年（范围为 3 至 18 年）。研究期间共有 13,120 人死亡。 5 年和 10 年因任何原因死亡的比例分别为 15.4%（95% 置信区间 [CI]，15.0% 至 15.8%）和 41.0%（95% CI，40.4% 至 41.6%）。共有 3,852 例 HNSCC 死亡，包括原发性和继发性头颈部肿瘤。鼻咽癌或下咽癌患者以及局部晚期疾病患者死于 HNSCC 的风险更大。 SPM 是非 HNSCC 死亡的主要原因，SPM 最常见的死亡部位是肺癌 (53%)、食道癌 (10%) 和结直肠癌 (5%)。许多 HNSCC 长期幸存者死于 HNSCC 以外的癌症和非癌症原因。对 HNSCC 幸存者的常规随访护理不应仅限于监测复发和新发头颈癌。
Survivors of head and neck squamous cell carcinoma (HNSCC) face excess mortality from multiple causes. We used population-based Surveillance, Epidemiology, and End Results (SEER) cancer registry data to evaluate the causes of death in patients with non-metastatic HNSCC diagnosed between 1992 and 2005 who survived at least three years from diagnosis (long-term survivors). We used competing-risks proportional hazards regression to estimate probabilities of death from causes: HNSCC, second primary malignancy (SPM) excluding HNSCC, cardiovascular disease (CVD), and other causes. We identified 35,958 3-year survivors of HNSCC with a median age at diagnosis of 60 years (range 18 to 100 years) and a median follow-up of 7.7 years (range 3 to 18 years). There were 13,120 deaths during the study period. Death from any cause at 5 and 10 years was 15.4% (95% confidence interval [CI], 15.0% to 15.8%) and 41.0% (95% CI, 40.4% to 41.6%), respectively. There were 3,852 HNSCC deaths including both primary and subsequent head and neck tumors. The risk of death from HNSCC was greater in patients with nasopharynx or hypopharynx cancer and in patients with locally advanced disease. SPM was the leading cause of non-HNSCC death, and the most common sites of SPM death were lung (53%), esophagus (10%), and colorectal (5%) cancer. Many long-term HNSCC survivors die from cancers other than HNSCC and from non-cancer causes. Routine follow-up care for HNSCC survivors should expand beyond surveillance for recurrence and new head and neck cancers.
登录
查看更多内容
影响因子：
11.5
作者：
Argiris, A;Brockstein, BE;Vokes, EE
通讯作者：
Vokes, EE
影响因子：
45.3
作者：
Mell, Loren K.;Dignam, James J.;Weichselbaum, Ralph R.
通讯作者：
Weichselbaum, Ralph R.
影响因子：
39.2
作者：
Lloyd-Jones, DM;Martin, DO;Levy, D
通讯作者：
Levy, D
影响因子：
6.2
作者：
Fuller, Clifton D.;Wang, Samuel J.;Rosenthal, David I.
通讯作者：
Rosenthal, David I.
影响因子：
45.3
作者：
Morris, Luc G. T.;Sikora, Andrew G.;Ganly, Ian
通讯作者：
Ganly, Ian