Do infants exhibit significant cortisol reactivity to the Face-to-Face Still-Face paradigm? A narrative review and meta-analysis
Do infants exhibit significant cortisol reactivity to the Face-to-Face Still-Face paradigm? A narrative review and meta-analysis
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DOI：
10.1016/j.dr.2016.07.001
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发表时间：
2016-12-01
影响因子：
6.6
通讯作者：
Montirosso, Rosario
中科院分区：
文献类型：
--
作者：
Provenzi, Livio;Giusti, Lorenzo;Montirosso, Rosario
面对面-静止-脸（FFSF）范式是一种广泛采用的实验程序，用于评估婴儿在出生后最初几个月对社会情绪压力的反应。先前的研究表明，这一过程引发了特定的行为反应，包括负面情绪和凝视厌恶的增加，以及积极情绪和社会参与的减少。婴儿也表现出下丘脑-垂体-肾上腺轴对FFSF的反应性。不幸的是，之前的研究报告了在出生后的头几个月里，FFSF范式暴露与HPA激活之间的关系不一致。本文采用文献综述和meta分析的方法对FFSF应力调节的HPA轴相关因子进行了研究。在三个数据库（即Scopus、Web of Science、PubMed）中进行文献检索，17项研究被纳入综述，10项研究被纳入meta分析。研究结果表明，尽管在方法和样本特征上有相当大的差异，但在FFSF范式引发的社会情绪压力下，婴儿倾向于表现出明显可观察到的下丘脑轴激活。五次重复暴露的FFSF手术被认为是更适合引起显著神经内分泌反应的手术。综上所述，FFSF似乎在社会情绪压力下引起HPA轴的激活，但仅在特定的情境条件下。因此，FFSF的研究工作仍然存在一些悬而未决的问题，需要继续下去。(C) 2016 Elsevier Inc.版权所有。
The Face-to-Face Still-Face (FFSF) paradigm is a widely adopted experimental procedure to assess infants' response to socio-emotional stress during the first months of life. Previous reviews demonstrated that this procedure elicits specific behavioral responses, including an increase in negative emotionality and gaze aversion as well as a decrease in positive emotionality and social engagement. Infants also give evidence of hypothalamic-pituitary adrenal (HPA) axis reactivity to the FFSF. Unfortunately, previous studies reported inconsistencies in the association between the exposure to the FFSF paradigm and HPA activation during the first months of life. In this paper, the HPA axis correlates of FFSF stress regulation were examined through a narrative review and a meta analysis. A literature search was conducted on three databases (i.e., Scopus, Web of Science, PubMed) and led to 17 studies included in the review and 10 included in the meta-analysis. The findings suggested that infants tend to show a clearly observable activation of the HPA axis in response to the socio-emotional stress elicited by the FFSF paradigm, although considerable variation in methodology and sample characteristics was documented. A five-episode repeated-exposure version of the FFSF procedure emerged as a more suitable procedure to elicit a significant neuroendocrine response. In summary, the FFSF appears to elicit HPA axis activation in response to socio-emotional stress, but only in specific contextual conditions. As such, open questions remain and require continuity in FFSF research efforts. (C) 2016 Elsevier Inc. All rights reserved.