Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans
Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans
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DOI：
10.1016/j.jnutbio.2004.11.006
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发表时间：
2005-03-01
影响因子：
5.6
通讯作者：
Testolin, G
中科院分区：
文献类型：
--
作者：
Erba, D;Riso, P;Testolin, G
绿色茶（GT）的抗氧化活性已被广泛研究，然而，从饮食干预研究中获得的结果是有争议的。在本研究中，我们调查了添加两杯GT的效果，（含有大约250毫克的总儿茶素）与对照饮食的比较。血浆中的抗氧化状态和脂质分布，对脂质和DNA氧化损伤的抵抗力，在试验开始和结束时测定淋巴细胞谷胱甘肽过氧化物酶（GPX）活性。42天后，摄入GT导致血浆总抗氧化活性显著增加[从1.79 μ mol Trolox当量（TE）/ml增加到1.98 μ mol Trolox当量（TE）/ml，P <0.001]，血浆过氧化物水平显著降低，（从412到288卡尔U，P < .05），并诱导淋巴细胞DNA氧化损伤（从尾部DNA的14.2%至10.1%，P < .05），相对于对照，LDL胆固醇中度但显著降低（从119.9至106.6mg/dL，P < .05）。本研究表明，GT的能力，在一个平衡的控制饮食中消费，以改善整体的抗氧化状态，并防止氧化损伤的人。(c)2005年爱思唯尔公司All rights reserved.
The antioxidant activity of green tea (GT) has been extensively studied; however, the results obtained from dietary intervention studies are controversial. In the present study we investigated the effect of the addition of two cups of GT (containing approximately 250 mg of total catechins) to a controlled diet in a group of healthy volunteers with respect to a group following the same controlled diet but not consuming GT. Antioxidant status and lipid profile in plasma, the resistance from oxidative damage to lipid and DNA, and the activity of glutathione peroxidase (GPX) in isolated lymphocytes were measured at the beginning and the end of the trial. After 42 days, consumption of GT caused a significant increase in plasma total antioxidant activity [from 1.79 to 1.98 mu mol Trolox equivalent (TE)/ml, P < .001], significant decreases in plasma peroxides level (from 412 to 288 Carr U, P < .05) and induced DNA oxidative damage in lymphocytes (from 14.2% to 10.1% of DNA in tail, P < .05), a moderate although significant decrease in LDL cholesterol (from 119.9 to 106.6 mg/dL, P < .05) with respect to control. The present study suggests the ability of GT, consumed within a balanced controlled diet, to improve overall the antioxidative status and to protect against oxidative damage in humans. (c) 2005 Elsevier Inc. All rights reserved.