Implication of Sialidases in Salmonella Infection: Genome Release of Sialidase Knockout Strains from Salmonella enterica Serovar Typhimurium LT2
Implication of Sialidases in Salmonella Infection: Genome Release of Sialidase Knockout Strains from Salmonella enterica Serovar Typhimurium LT2
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DOI：
10.1128/genomea.00341-17
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发表时间：
2017-05-01
期刊：
影响因子：
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通讯作者：
Weimer, Bart C.
中科院分区：
文献类型：
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作者：
Arabyan, Narine;Weis, Allison M.;Weimer, Bart C.
唾液酸酶广泛存在于自然界中，其作用是切割唾液酸末端的α-酮苷键。这些新出现的毒力因子降解宿主聚糖。我们在这里报告的释放7唾液酸酶和一个唾液酸转运蛋白缺失肠道沙门氏菌血清型鼠伤寒沙门氏菌菌株LT 2，这是重要的细胞入侵感染期间。
Sialidases, which are widely distributed in nature, cleave the alpha-ketosidic bond of terminal sialic acid residue. These emerging virulence factors degrade the host glycan. We report here the release of seven sialidase and one sialic acid transporter deletion in Salmonella enterica serovar Typhimurium strain LT2, which are important in cellular invasion during infection.