Familial aggregation of physical activity levels in the Quebec family study
Familial aggregation of physical activity levels in the Quebec family study
复制标题
DOI：
10.1097/00005768-200207000-00014
复制
发表时间：
2002-07-01
期刊：
影响因子：
--
通讯作者：
Bouchard, C
中科院分区：
文献类型：
--
作者：
Simonen, RL;Pérusse, L;Bouchard, C
目的：在来自魁北克家庭研究的200个家庭的696名受试者中调查了体力活动表型的家庭聚集性。后代和父母的平均年龄分别为27岁和53岁。方法：在过去的一年中，使用3-D日记和一份关于体力活动的问卷来估计体力活动的水平。结果如下：对年龄和性别校正的体力活动表型进行的方差分析显示，家庭间体力活动水平的变异是家庭内的1.40-1.52倍（0.001 < P <0.0001）。这表明家庭中的体育活动水平是聚集的。最大遗传力（SEGPATH），调整配偶相似度，达到25%，16%，19%。和17%的不活动的程度，在中度到剧烈的体力活动，日常活动的总水平，以及在过去一年中的主要活动每周花费的时间，分别。结论：这些结果表明，体力活动水平的特点是一个显着程度的家族相似性，不活动有一个略高于中度到剧烈的体力活动或总体力活动表型的遗传水平。家族相关性的模式表明，共同的家庭环境因素沿着遗传因素在解释体力活动水平的家族相似性方面也很重要。
Purpose: Familial aggregation of physical activity phenotypes was investigated in 696 subjects from 200 families of the Quebec Family Study. The mean age of offspring and parents was 27 and 53 yr, respectively. Methods: The levels of physical activity were estimated using a 3-d diary and a questionnaire dealing with physical activity during the past year. Results: An ANOVA performed on the age and sex adjusted physical activity phenotypes revealed that there were 1.40-1.52 times more variation in physical activity levels between families than within families (0.001 < P < 0,0001). suggesting that physical activity levels aggregate in families. Maximal heritabilities (SEGPATH), adjusted for the degree of spouse resemblance, reached 25%, 16%, 19%. and 17% for the degree of inactivity, time spent in moderate to strenuous physical activities, total level of daily activity, and weekly time spent in the main activity during the previous year, respectively. Conclusion: These results suggest that physical activity level is characterized by a significant degree of familial resemblance, and that inactivity has a slightly higher heritability level than moderate to strenuous physical activity or total physical activity phenotypes. The pattern of familial correlations suggests that shared familial environmental factors along with genetic factors are also important in accounting for the familial resemblance in physical activity level.