Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic
Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic
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DOI：
10.1192/bjp.181.43.s30
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发表时间：
2002-09-01
影响因子：
10.5
通讯作者：
Pukrop, R
中科院分区：
文献类型：
--
作者：
Hambrecht, M;Lammertink, M;Pukrop, R
背景
预测向精神病的转变是困难的。神经心理学可能有助于预测。
目的
报告德国第一家早期识别中心前驱期患者自我感知和客观可测量的神经认知的初步数据。
方法
对51名具有潜在精神分裂症前驱症状的患者评估主观神经心理障碍。将初始神经认知功能与匹配的正常人和精神分裂症患者进行比较。
结果
自我感知的缺陷主要涉及感知、认知和应激反应性。在15个月的随访期间发生了5次转变。近期出现或加重的缺陷在一定程度上可预测转变。高危人群在客观测量的语言能力、注意力和记忆功能方面比对照组表现更差。
结论
神经心理缺陷，无论是自我感知的还是客观测量的，都是精神分裂症高危人群的特征，并可能有助于预测转变。
利益声明
由科隆医学院（科隆财富）和德国联邦教育与研究部（BMBF）、德国精神分裂症研究网络（资助编号01 GI 993x）资助。
Background Predicting transitions to psychosis is difficult. Neuropsychology might facilitate predictions.Aims To report preliminary data on self-perceived and objectively measurable neurocognition in prodromal patients of the first German early recognition centre.Method Subjective neuropsychological disturbances were assessed in 51 patients with potentially prodromal symptoms of schizophrenia. Initial neurocognitive functioning was compared with matched normals and patients with schizophrenia.Results Self-perceived deficits mostly concerned perception, cognition and stress reactivity Five transitions happened during the 15-month follow-up. Recently emerging or intensifying deficits were to some extent predictive of transition. Persons at risk performed worse than controls on objectively measured verbal capacity, attention and memory functions.Conclusions Neuropsychological deficits, either self-perceived or objectively measured, characterise persons at risk for schizophrenia and may contribute to predicting transitions.Declaration of interest Funded by the Cologne Faculty of Medicine (Koln Fortune) and Federal Ministry for Education and Research BMBF, German Schizophrenia Research Network (grant 01 GI 993x).