FASCICLIN-II CONTROLS PRONEURAL GENE-EXPRESSION IN DROSOPHILA
FASCICLIN-II CONTROLS PRONEURAL GENE-EXPRESSION IN DROSOPHILA
复制标题
DOI：
10.1073/pnas.92.23.10501
复制
发表时间：
1995-11-07
影响因子：
11.1
通讯作者：
GOODMAN, CS
中科院分区：
文献类型：
--
作者：
GARCIAALONSO, L;VANBERKUM, MFA;GOODMAN, CS
Fascilin II (Fas II) 是果蝇中的一种 NCAM 样细胞粘附分子，在胚胎轴突的子集上表达并控制选择性轴突束颤，Fas II 也在成虫盘中表达。在这里，我们使用遗传分析表明，Fas II 是控制原神经基因表达所必需的，眼触角成神经盘中的细胞簇表达 achaete 原神经基因并产生机械感觉神经元；其他细胞簇表达无调性基因并产生眼部感光神经元。在 fasII 功能丧失突变体中，两个原神经基因的表达在某些位置缺失，因此，相应的感觉前体细胞无法发育。在 fasII 功能获得条件下，额外的感觉结构从成虫盘的同一区域产生。 Abelson 酪氨酸激酶基因的突变显示出与 fasII 突变的显着相互作用，表明 Abl 和 Fas II 在控制原神经基因表达的信号通路中发挥作用。
Fasciclin II (Fas II), an NCAM-like cell adhesion molecule in Drosophila, is expressed on a subset of embryonic axons and controls selective axon fasciculation, Fas II is also expressed in imaginal discs. Here we use genetic analysis to show that Fas II is required for the control of proneural gene expression, Clusters of cells in the eye-antennal imaginal disc express the achaete proneural gene and give rise to mechanosensory neurons; other clusters of cells express the atonal gene and give rise to ocellar photoreceptor neurons, In fasII loss-of-function mutants, the expression of both proneural genes is absent in certain locations, and, as a result, the corresponding sensory precursors fail to develop, In fasII gain-of-function conditions, extra sensory structures arise from this same region of the imaginal disc. Mutations in the Abelson tyrosine kinase gene show dominant interactions with fasII mutations, suggesting that Abl and Fas II function in a signaling pathway that controls proneural gene expression.