Widespread genetic incompatibility in C. elegans maintained by balancing selection
Widespread genetic incompatibility in C. elegans maintained by balancing selection
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DOI：
10.1126/science.1151107
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发表时间：
2008-02-01
期刊：
影响因子：
56.9
通讯作者：
Kruglyak, Leonid
中科院分区：
文献类型：
--
作者：
Seidel, Hannah S.;Rockman, Matthew V.;Kruglyak, Leonid
自然选择有望消除杂交种群中的遗传不相容性。我们已经发现了一个全球性分布的主要自交种秀丽隐杆线虫的不相容性，一直保持尽管其负面后果健身。如果精子亲本携带第二个父本效应基因peel- 1的不相容等位基因，则合子作用基因zeel- 1天然缺失的纯合子胚胎会停滞。这两个相互作用的基因座紧密连锁，不相容的等位基因发生在两个常见的单倍型连锁不平衡。这些单倍型表现出升高的序列差异，该地区的群体遗传分析表明，自然选择是保存在人口中的单倍型。我们的数据表明，尽管基因组的其余部分发生了基因流动，但平衡的多态性的长期维持使得不相容性持续存在。
Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel- 1 arrest if their sperm parent carries an incompatible allele of a second, paternal- effect locus, peel- 1. The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes. These haplotypes exhibit elevated sequence divergence, and population genetic analyses of this region indicate that natural selection is preserving both haplotypes in the population. Our data suggest that long- term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome.