Telomeres and Tissue Engineering: The Potential Roles of TERT in VEGF-mediated Angiogenesis
Telomeres and Tissue Engineering: The Potential Roles of TERT in VEGF-mediated Angiogenesis
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DOI：
10.1007/s12015-012-9414-3
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发表时间：
2012-12-01
影响因子：
4.8
通讯作者：
Demarco, Flavio F.
中科院分区：
文献类型：
--
作者：
Hartwig, Fernando P.;Nedel, Fernanda;Demarco, Flavio F.
端粒是位于真核生物染色体末端的保护性结构，每次细胞分裂后端粒缩短，导致衰老。端粒酶活性通过被称为TERT（端粒酶逆转录酶）的亚基催化的逆转录来防止端粒缩短。TERT表达已显示出有趣的细胞特性，这可能对组织工程有吸引力，如体外增强细胞增殖和分化能力。尽管有证据表明TERT在VEGF（血管内皮生长因子）介导的血管生成中发挥了这些作用，但目前尚不清楚TERT是否能参与这一产生功能器官的重要事件。本综述提出了一个假设，即TERT和VEGF可能相互调节转录表达，这将为端粒酶在调节几种细胞过程中的作用提供新的视角，也有助于更好地理解VEGF信号传导（旁分泌和自分泌）的分子机制。总的来说，根据修订的文献，可以得出TERT是一种潜在的VEGF增强剂的结论；然而，有必要详细阐述方法学方法来探索这种潜力并评估组织工程方法的潜在好处。
Telomeres are protective structures located at the end of eukaryotic chromosomes which are shortened after each cell division, leading to senescence. Telomerase activity prevents telomere shortening by reverse transcription catalyzed by the subunit called TERT (telomerase reverse transcriptase). TERT expression has shown interesting cellular properties, which may be appealing for tissue engineering, such as the enhancement of cell proliferation and differentiation abilities in vitro. Despite some evidence for playing these roles in VEGF (vascular endothelial growth factor)-mediated angiogenesis, it is still unclear whether TERT can contribute to this essential event to generate functional organs. This review suggests a hypothesis that TERT and VEGF potentially regulates the transcriptional expression of each other, which would give new perspectives in the roles of telomerase in regulating several cellular processes, and also contributing for a better comprehension of the molecular mechanisms underlying VEGF signaling (both paracrine and autocrine). In general, based on the literature revised, it is possible to conclude that TERT is a potential VEGF enhancer; however, it is necessary to elaborate methodological approaches to explore this potential and to assess the potential benefits on tissue engineering approaches.