Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene.
Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene.
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DOI：
10.1073/pnas.78.10.6191
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发表时间：
1981-10
影响因子：
11.1
通讯作者：
J. Keene;B. J. Thornton;S. Emerson
中科院分区：
文献类型：
--
作者：
J. Keene;B. J. Thornton;S. Emerson
水疱性口炎病毒核衣壳的甲基化保护研究表明，病毒聚合酶（L蛋白和NS蛋白）与前导基因中间的基因组RNA模板接触，距离3'端16-30个核苷酸。数据表明，NS蛋白与序列结合（公式，见文本），并可能作为转录的启动蛋白。
Methylation-protection studies with nucleocapsids from vesicular stomatitis virus indicate that the viral polymerase (L and NS proteins) contacts the genomic RNA template in the middle of the leader gene, 16-30 nucleotides from the 3' terminus. The data suggest that the NS protein binds to the sequence (formula, see text) and may function as an initiator protein for transcription.