Exploring response inhibition and error monitoring in obsessive-compulsive disorder.
Exploring response inhibition and error monitoring in obsessive-compulsive disorder.
复制标题
DOI：
10.1016/j.jpsychires.2020.04.002
复制
发表时间：
2020-04
影响因子：
4.8
通讯作者：
Vitor Portella Silveira;I. Frydman;Leonardo Franklin Fontenelle;P. Mattos;R. de Oliveira-Souza;J. Moll;M. Hoexter;E. Miguel;N. McLaughlin;E. Shephard;M. Batistuzzo
中科院分区：
文献类型：
--
作者：
Vitor Portella Silveira;I. Frydman;Leonardo Franklin Fontenelle;P. Mattos;R. de Oliveira-Souza;J. Moll;M. Hoexter;E. Miguel;N. McLaughlin;E. Shephard;M. Batistuzzo
强迫症(OCD)的反应抑制受损(RI)和多动错误监测(EM)的行为证据不一致。最近的神经成像研究表明，EM在强迫症的RI损害中发挥了作用，但很少有人使用行为测量来研究这一点。本研究的目的是(1)比较成人强迫症患者和非精神控制(NPC)患者的RI和EM表现，同时调查可能的调节因素，以及(2)评估过度EM是否影响强迫症患者的RI。我们比较了来自巴西两个地点的92名强迫症成人和65名鼻咽癌患者在停止信号任务(SST)上的RI和EM表现。我们使用线性回归来调查哪些变量(组、年龄、用药情况、临床症状)影响表现，并检查RI和EM之间的可能关联。强迫症和鼻咽癌的RI和EM差异无统计学意义。然而，年龄降低了强迫症患者的RI表现，其效应大小适中，反映了年龄对RI的不同影响：年龄与强迫症患者的RI呈正相关，但与鼻咽癌无关。此外，强迫症的严重程度预测EM的效果大小从中到大，这表明更多的有症状的患者对他们的错误表现出更好的监测。最后，团体以较小的效应量调节了RI与EM之间的关系。我们的研究结果表明，人口统计学因素可能影响RI，而临床因素可能影响EM。此外，我们还发现了初步的行为学证据，表明强迫症患者RI受损和EM过多有关。
Behavioral evidence of impaired response inhibition (RI) and hyperactive error monitoring (EM) in obsessive-compulsive disorder (OCD) is inconsistent. Recent neuroimaging work suggests that EM plays a role in RI impairments in OCD, but this has rarely been investigated using behavioral measures. The aims of this study were to (1) compare RI and EM performance between adults with OCD and non-psychiatric controls (NPC) while investigating possible moderators, and (2) assess whether excessive EM influences RI in OCD. We compared RI and EM performance on the Stop-Signal Task (SST) between 92 adults with OCD and 65 NPC from two Brazilian sites. We used linear regression to investigate which variables (group, age, medication use, clinical symptomatology) influenced performance, as well as to examine possible associations between RI and EM. OCD and NPC did not differ in RI and EM. However, age moderated RI performance in OCD with a medium effect size, reflecting differential effects of age on RI between groups: age was positively associated with RI in OCD but not NPC. Further, OCD severity predicted EM with a medium to large effect size, suggesting that more symptomatic patients showed greater monitoring of their mistakes. Finally, group moderated the relationship between RI and EM with a small effect size. Our findings suggest that demographic factors may influence RI, whereas clinical factors may influence EM. Further, we found preliminary behavioral evidence to indicate that impaired RI and excessive EM are related in OCD.