Release of oxytocin into blood and cerebrospinal fluid by electrical stimulation of the hypothalamus or neural lobe in the rat.
Release of oxytocin into blood and cerebrospinal fluid by electrical stimulation of the hypothalamus or neural lobe in the rat.
复制标题
通过电刺激大鼠下丘脑或神经叶将催产素释放到血液和脑脊液中。
作者：
P. Jones;I. Robinson;M. Harris
催产素（OT）的测定从麻醉大鼠的血液和脑脊液（CSF）样品。通过电刺激下丘脑或神经叶（15 s）诱发OT的释放。刺激神经叶使血浆OT增加7倍而不改变CSF水平。下丘脑刺激释放OT到血液和CSF中，尽管CSF中的升高与血浆中的升高相比既延迟又延长。将OT释放到CSF中的刺激部位延伸到下丘脑的大内侧区域。更多的侧向刺激部位效果差得多。我们的研究结果表明，OT释放到血液和CSF中可以分离，CSF水平反映了下丘脑OT神经元的活性，这些神经元不投射到神经叶。
Oxytocin (OT) was measured in blood and cerebrospinal fluid (CSF) samples obtained from anaesthetized rats. Release of OT was evoked by electrical stimulation (15 s) of the hypothalamus or the neural lobe. Stimulation of the neural lobe increased plasma OT sevenfold without altering CSF levels. Hypothalamic stimulation released OT into both blood and CSF, although the rise in CSF was both delayed and prolonged compared to that in plasma. Stimulation sites which released OT into CSF extended over a large medial area of the hypothalamus. More lateral stimulation sites were much less effective. Our results show that the release of OT into blood and CSF can be dissociated and that CSF levels reflect the activity of those hypothalamic OT-neurones which do not project to the neural lobe.