Tumour-stroma interaction:: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
Tumour-stroma interaction:: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
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DOI：
10.1016/j.lungcan.2004.07.977
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发表时间：
2004-08-01
期刊：
影响因子：
5.3
通讯作者：
Östman, A
中科院分区：
文献类型：
--
作者：
Micke, P;Östman, A
基质细胞与细胞外基质成分一起提供了对癌细胞生长、侵袭和转移进展至关重要的微环境。特征性间质改变伴随或甚至先于上皮细胞的恶性转化。在此过程中至关重要的是位于肿瘤上皮附近的成纤维细胞，也称为肌成纤维细胞或癌症相关成纤维细胞（CAF）。细胞它们能够改变上皮细胞的表型。通过直接的细胞与细胞接触，通过可溶性因子或通过修饰细胞外基质成分来调节细胞。对各种癌症类型，包括乳腺癌、结肠癌、前列腺癌和肺癌的精液功能研究证实了成纤维细胞可以决定上皮细胞命运的概念，因为它们能够促进恶性转化以及使肿瘤细胞恢复正常表型。本文综述了成纤维细胞在癌症中的特征性变化，并提供了阐明CAFs在致癌过程中功能特性的实验背景。一个可能的影响，在肺癌的发生是强调。最后，提出了一种基于激光捕获和微阵列的方法，该方法全面表征了癌相关成纤维细胞在其体内环境中的抗癌治疗的潜在靶点的识别。(C)2004 Elsevier Science Ltd.
Stroma cells, together with extracellular matrix components, provide the microenvironment that is pivotal for cancer cell growth, invasion and metastatic progression. Characteristic stroma alterations accompany or even precede the malignant conversion of epithelial cells. Crucial in this process are fibroblasts, also termed myofibroblasts or cancer-associated fibroblasts (CAFs) that are located in the vicinity of the neoplastic epithelial. cells. They are able to modify the phenotype of the epithelial. cells by direct cell-to-cell contacts, through soluble factors or by modification of extracellular matrix components. Seminal functional studies in various cancer types, including breast, colon, prostate and lung cancer, have confirmed the concept that fibroblasts can determine the fate of the epithelial cell, since they are able to promote malignant conversion as well as to revert tumour cells to a normal phenotype. This review focuses on characteristic changes of fibroblasts in cancer and provides the experimental background elucidating functional properties of CAFs in the carcinogenic process. A possible implication in lung carcinogenesis is emphasised. Finally, a laser-capture- and microarray-based approach is presented, which comprehensively characterises carcinoma-associated fibroblasts in their in vivo environment for the identification of potential targets for anti-cancer therapy. (C) 2004 Elsevier Science Ltd.