Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4+T cells
Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4+T cells
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DOI：
10.1016/j.bbrc.2009.06.027
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发表时间：
2009-08-21
影响因子：
3.1
通讯作者：
Morimoto, Chikao
中科院分区：
文献类型：
--
作者：
Ohnuma, Kei;Uchiyama, Masahiko;Morimoto, Chikao
CD 26与抗原呈递细胞（APC）中的小窝蛋白-1结合，并且通过小窝蛋白-1连接CD 26以TCR/CD 3依赖性方式诱导T细胞增殖。我们在此报道了融合蛋白caveolin-1-IG（Cav-1g）对CD 26-caveolin-1共刺激信号的阻断作用。可溶性Cav-Ig抑制T细胞增殖和响应于回忆抗原或同种异体APC的细胞因子产生。因此，我们的数据表明，通过可溶性Cav-Ig阻断CD 26相关信号传导可能是免疫抑制治疗的有效方法。(C)2009 Elsevier Inc. All rights reserved.
CD26 binds to caveolin-1 in antigen-presenting cells (APC), and that ligation of CD26 by caveolin-1 induces T cell proliferation in a TCR/CD3-dependent manner. We report herein the effects of CD26-caveolin-1 costimulatory blockade by fusion protein caveolin-1-Ig (Cav-1g). Soluble Cav-Ig inhibits T cell proliferation and cytokine production in response to recall antigen, or allogeneic APC. Our data hence suggest that blocking of CD26-associated signaling by soluble Cav-Ig may be an effective approach as immunosuppressive therapy. (C) 2009 Elsevier Inc. All rights reserved.