The effect of intracarotid vasopressin infusion on ACTH release in neurohypophysectomized, conscious dogs.
The effect of intracarotid vasopressin infusion on ACTH release in neurohypophysectomized, conscious dogs.
复制标题
颈动脉内加压素输注对神经垂体切除的清醒犬 ACTH 释放的影响。
DOI：
10.1152/ajpregu.1994.267.3.r653
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
CowleyJr,AW
中科院分区：
文献类型：
--
作者：
Raff,H;Papanek,PE;Liard,JF;CowleyJr,AW
神经垂体切除术（NHX）减弱促肾上腺皮质激素（ACTH）对动脉低血压的反应，但不减弱促肾上腺皮质激素释放激素（CRH）或胰岛素诱导的清醒犬低血糖。本研究的目的是确定通过颈动脉灌注增加头循环中的加压素（AVP）是否使ACTH对NHX减弱的低血压的反应正常化。在选择性NHX之前和之后> 4周，通过输注硝普钠（NP），对5只雄性条件犬进行了动脉压的控制性急性降低（约25 mmHg）。在完整状态下，NP期间ACTH从40 +/- 3增加到242 +/- 79 pg/ml。在NHX后，这种反应大大减弱（峰值ACTH 81 +/- 15 pg/ml）。同时静脉输注AVP（12.5 ng/min）对ACTH对NP的反应（峰值ACTH 120 +/- 27 pg/ml）具有较小的增强作用。颈动脉内AVP（12.5 ng/min）极大地增强了ACTH对NP的反应（峰值ACTH 202 +/- 26 pg/ml），使得其与完整反应不再不同。静脉内或颈动脉内注射AVP本身对ACTH均无显著影响。正常的ACTH对低血压的反应需要完整的神经垂体，并由大细胞AVP的头部作用介导。
Neurohypophysectomy (NHX) attenuates the adrenocorticotropic hormone (ACTH) response to arterial hypotension but not corticotropin-releasing hormone (CRH) or insulin-induced hypoglycemia in conscious dogs. The purpose of the present study was to determine if increasing vasopressin (AVP) in the cephalic circulation by carotid infusion normalizes the ACTH response to hypotension attenuated by NHX. Five male, conditioned dogs underwent controlled, acute decreases in arterial pressure (by approximately 25 mmHg) by infusion of sodium nitroprusside (NP) before and > 4 wk after selective NHX. ACTH increased from 40 +/- 3 to 242 +/- 79 pg/ml during NP in the intact state. This response was greatly attenuated after NHX (peak ACTH 81 +/- 15 pg/ml). Simultaneous intravenous infusion of AVP (12.5 ng/min) had a small, augmenting effect on the ACTH response to NP (peak ACTH 120 +/- 27 pg/ml). Intracarotid AVP (12.5 ng/min) greatly augmented the ACTH response to NP (peak ACTH 202 +/- 26 pg/ml) such that it was no longer different from the intact response. Neither intravenous nor intracarotid AVP infusion per se had a great effect on ACTH. A normal ACTH response to hypotension requires an intact neurohypophysis and is mediated by a cephalic action of magnocellular AVP.