Plasma zinc concentrations of mothers and the risk of nonsyndromic oral clefts in their children: a case-control study in the Philippines.
Plasma zinc concentrations of mothers and the risk of nonsyndromic oral clefts in their children: a case-control study in the Philippines.
复制标题
母亲的血浆锌浓度及其子女非综合征性口裂的风险：菲律宾的一项病例对照研究。
DOI：
10.1002/bdra.20179
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
F. Solon
中科院分区：
文献类型：
--
作者：
T. Tamura;R. Munger;C. Corcoran;Jocelyn Y Bacayao;B. Nepomuceno;F. Solon
BACKGROUND
Findings from animal experiments suggest a link between poor maternal zinc status and increased risk of oral clefts in offspring; however, there are few human studies on this issue.
METHODS
A case-control study was conducted using 74 case mothers of children with nonsyndromic cleft lip with or without cleft palate (CL/P, n=57) or cleft palate alone (CP, n=17), and 283 control mothers of unaffected children recruited in the Philippines in early 2003. Maternal zinc status was assessed by determining plasma zinc concentrations a mean of 5 years after delivery of the index child. Odds ratios (ORs) of estimates of the relative risk of oral clefts were calculated for quartiles of maternal plasma zinc concentrations.
RESULTS
The mean plasma zinc concentration of CL/P case mothers (9.6+/-1.2, SD micromol/l) was significantly lower than that in control mothers (10.1+/-1.6 micromol/l; P<0.05). Low plasma zinc concentrations (<11.0 micromol/l) were found in 88% and 94% of CL/P and CP case mothers, respectively, and in 72% of controls (P<0.05). The ORs for CL/P and CP combined, adjusted for potential confounding factors, decreased with increasing quartile of plasma zinc as follows: 1.0 (lowest quartile reference), 0.83 (95% confidence interval 0.37-1.89), 0.70 (0.31-1.68), and 0.26 (0.10-0.70) (P trend=0.008).
CONCLUSIONS
Low plasma zinc concentrations were common in Filipino women of reproductive age, and higher plasma zinc concentrations were associated with a lower risk for oral clefts in their children.
影响因子：
5.4
作者：
Devine, CM;Bove, CF;Olson, CM
通讯作者：
Olson, CM
膳食引起的成年女性血浆、红细胞和尿锌浓度的变化。
DOI：
10.1093/ajcn/58.5.695
发表时间：
1993
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Wallock,LM;King,JC;Hambidge,KM;English-Westcott,JE;Pritts,J
通讯作者：
Pritts,J