OPTICAL COHERENCE TOMOGRAPHY OF MACULAR HOLES
OPTICAL COHERENCE TOMOGRAPHY OF MACULAR HOLES
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DOI：
10.1016/s0161-6420(95)30959-1
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发表时间：
1995-05-01
期刊：
影响因子：
13.7
通讯作者：
FUJIMOTO, JG
中科院分区：
文献类型：
--
作者：
HEE, MR;PULIAFITO, CA;FUJIMOTO, JG
目的：评估一种新的诊断技术，称为光学相干断层扫描（OCT）的诊断和监测黄斑裂孔的潜力。这种技术是一种新型的非侵入性，非接触式成像方式，产生高纵向分辨率（10 μ m）的横截面断层扫描的眼tissue.Methods：光学相干断层扫描是类似于超声波除了光学，而不是声学反射率进行测量。在一个薄的光学切片的组织中，视网膜剖面光学反射率的横截面断层摄影得到的纵向分辨率为10 μ m。应用光学相干断层扫描（OCT）对49例临床诊断为特发性全层黄斑裂孔、临近黄斑裂孔、黄斑前膜伴黄斑假性裂孔或部分黄斑裂孔的患者进行检查，并与接触透镜、裂隙灯显微镜、眼底照相和荧光素血管造影进行相关性分析。OCT产生的横截面视图在区分全层黄斑裂孔与部分层裂孔、黄斑假裂孔和囊肿方面是有效的。光学相干断层扫描成功地对黄斑裂孔进行了分期，并提供了裂孔直径和周围黄斑水肿量的定量测量。光学相干断层扫描也被用来评估玻璃体视网膜接口在患者的同胞眼睛，并能够检测到小的分离后玻璃体视网膜retina.Conclusion：光学相干断层扫描作为一种新的，非侵入性的，诊断技术的可视化和定量表征黄斑裂孔和评估同胞眼睛的黄斑裂孔患者出现潜在的有用。OCT提供的断层信息最终可能会导致更好地了解黄斑裂孔形成的发病机制。
Purpose: To assess the potential of a new diagnostic technique called optical coherence tomography (OCT) for diagnosing and monitoring macular holes. This technique is a novel noninvasive, noncontact imaging modality that produces high longitudinal resolution (10-mu m) cross-sectional tomographs of ocular tissue.Methods: Optical coherence tomography is analogous to ultrasound except that optical rather than acoustic reflectivity is measured. Cross-sectional tomographs of the retina profiling optical reflectivity in a thin, optical slice of tissue are obtained with a longitudinal resolution of 10 mu m. Optical coherence tomography was used to examine 49 patients with the clinical diagnosis of idiopathic full-thickness macular hole, impending macular hole, epimacular membrane with macular pseudohole, or partial-thickness hole, The resulting OCTs were correlated with contact lens and slit-lamp biomicroscopy, fundus photography, and fluorescein angiography.Results: The cross-sectional view produced by OCT was effective in distinguishing full-thickness macular holes from partial-thickness holes, macular pseudoholes, and cysts. Optical coherence tomography was successful in staging macular holes and provided a quantitative measure of hole diameter and the amount of surrounding macular edema. Optical coherence tomography also was used to evaluate the vitreoretinal interface in patients' fellow eyes and was able to detect small separations of the posterior hyaloid from the retina.Conclusion: Optical coherence tomography appears potentially useful as a new, noninvasive, diagnostic technique for visualizing and quantitatively characterizing macular holes and assessing fellow eyes of patients with a macular hole. The tomographic information provided by OCT eventually may lead to a better understanding of the pathogenesis of macular hole formation.