The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings.
The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings.
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DOI：
10.1007/s40572-015-0066-8
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发表时间：
2015-12
影响因子：
7.9
通讯作者：
Miller R
中科院分区：
文献类型：
--
作者：
Robinson L;Miller R
近年来，环境接触化学品的影响及其免疫学效应，包括过敏的发展，一直是人们非常感兴趣的话题。流行病学研究表明，接触大量产生的内分泌干扰物，包括双酚A(BPA)和邻苯二甲酸盐，是无处不在的。他们的暴露与过敏、哮喘和免疫功能障碍的发展之间的联系已经在体外、体内和通过人类队列研究进行了研究。这项审查的目的是检查目前的研究机构，并强调当前研究结果的不足和优势。新兴科学表明，有害的免疫变化可能正在发生，包括在饮食和吸入这些化学物质后出现喘息、过敏和哮喘的倾向增加。
In recent years, the impact of environmental exposure to chemicals and their immunological effects, including the development of allergy, has been a topic of great interest. Epidemiologic studies indicate that exposure to endocrine disrupting chemicals produced in high volumes, including bisphenol A (BPA) and phthalates, are ubiquitous. The links between their exposure and the development of allergy, asthma and immune dysfunction have been studied in vitro, in vivo and through human cohort studies. The purpose of this review is to examine the current body of research and to highlight deficits and strengths of current findings. Emerging science indicates that deleterious immunologic changes, including increased propensity to develop wheeze, allergy and asthma after dietary and inhalation exposure to these chemicals, may be occurring.