Bone mineral density in girls with forearm fractures
Bone mineral density in girls with forearm fractures
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DOI：
10.1359/jbmr.1998.13.1.143
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发表时间：
1998-01-01
影响因子：
6.2
通讯作者：
Lewis-Barned, NJ
中科院分区：
文献类型：
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作者：
Goulding, A;Cannan, R;Lewis-Barned, NJ
在儿童时期，最常见的骨折部位是前臂远端。为了确定患有这些骨折的年轻女孩是否比没有骨折的对照组更普遍地患有低骨密度，我们测量了100名3-15岁的高加索女孩、前臂远端骨折和100名年龄和性别匹配的对照组的桡骨、脊柱、髋部和全身的骨密度和全身骨矿含量、瘦组织质量和脂肪质量。骨密度(所有病例的年龄调整比率：对照组95%可信区间)在超远端0.963(0.930-0.996)、33%(0.945-0.999)、腰椎0.945(0.911-0.980)、髋部粗隆0.952(0.918-0.988)和全身0.978(0.961-0.995)处较低。此外，骨量减少(定义为Z评分低于-1)在前臂、脊柱和髋部比对照组(P<；0.05)更常见，三分之一的骨折病例脊柱密度低。低骨密度的优势比(95%可信区间)为：超骨桡骨，2.2(1.1-4.6)；腰椎，L2-L4，2.6(1.3-4.9)；股骨粗隆，2.0(1.0-3.9)。8-10岁的骨折患者的体重(平均+/-SD)高于年龄匹配的对照组(37.2+/-8.0千克比32.5+/-6.6千克，p<；0.01)，而年龄较大的患者报告的当前和过去的钙摄入量低于匹配的对照组(p<；0.05)。我们的结论是，与从未骨折的女孩相比，患有前臂骨折的女孩整个骨骼中的低骨密度更常见，这支持了低骨密度可能导致儿童骨折风险的观点。
In childhood, the most common site of fracture is the distal forearm. To determine whether young girls with these fractures have low bone density more commonly than fracture-free controls, we measured bone density at the radius, spine, hip, and whole body and total body bone mineral content, lean tissue mass, and fat mass by dual-energy X-ray absorptiometry in 100 Caucasian girls aged 3-15 years,vith recent distal forearm fractures and 100 age-and gender-matched controls. Bone density (age-adjusted ratios of all cases:controls with 95% confidence intervals) was lower in cases at the ultradistal radius 0.963 (0.930-0.996), 33% radius 0.972 (0.945-0.999), lumbar spine 0.945 (0.911-0.980), hip trochanter 0.952 (0.918-0.988), and total body 0.978 (0.961-0.995). Moreover, osteopenia (defined as Z score below -1), was more common in cases than controls (p < 0.05) in the forearm, spine, and hip, with one third of fracture cases having low spinal density. Odds ratios (95% confidence intervals) for low bone density were: ultradistal radius, 2.2 (1.1-4.6); lumbar spine, L2-L4, 2.6 (1.3-4.9); and femur trochanter, 2.0 (1.0-3.9). Fracture patients aged 8-10 years weighed more (mean +/- SD) than age-matched controls (37.2 +/- 8.0 kg vs. 32.5 +/- 6.6 kg, p < 0.01) while older patients reported lower current and past calcium intakes than matched controls (p < 0.05). We conclude that low bone density is more common throughout the skeleton in girls with forearm fractures than in those who have never broken a bone, supporting the view that low bone density may contribute to fracture risk in childhood.