GENETIC LESIONS INDUCED BY CHEMICALS IN SPERMATOZOA AND SPERMATIDS OF MICE ARE REPAIRED IN THE EGG
GENETIC LESIONS INDUCED BY CHEMICALS IN SPERMATOZOA AND SPERMATIDS OF MICE ARE REPAIRED IN THE EGG
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DOI：
10.1073/pnas.76.1.435
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发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
HUFF, SW
中科院分区：
文献类型：
--
作者：
GENEROSO, WM;CAIN, KT;HUFF, SW
通过对化学处理的精子和精子细胞进行显性致死研究，以及通过对第一卵裂中期的细胞学分析，获得了小鼠卵子能够修复雄性基因组中存在的遗传损伤的确凿证据。在甲磺酸异丙酯处理的雌性种群之间修复能力的最大差异很大；在甲磺酸乙酯、三乙胺和苯并[a]芘处理中发现的差异要小得多；而在X射线处理中没有发现差异。
Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of 1st-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine and benzo[a]pyrene treatments; and no difference was found for X-ray treatment.