Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiency.
Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiency.
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乳腺癌转移的分子生物学。实验研究对转移性效率低下的临床意义。
DOI：
10.1186/bcr86
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发表时间：
2000
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中科院分区：
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最近的技术进步使得检测患者血液、淋巴结或骨髓中的孤立肿瘤细胞和肿瘤细胞群的能力不断提高。然而，这些细胞的临床意义尚不清楚。它们是否应该被认为是转移的证据，需要积极的治疗，或者在某些情况下它们与临床结果无关？对转移性低效率的基础生物学的定量实验研究提供了可能有助于理解这些细胞的重要性的线索。这种理解将用于指导临床研究，以评估孤立的肿瘤细胞和微转移在癌症患者中的意义。
Recent technological advances have led to an increasing ability to detect isolated tumour cells and groups of tumour cells in patients' blood, lymph nodes or bone marrow. However, the clinical significance of these cells is unclear. Should they be considered as evidence of metastasis, necessitating aggressive treatment, or are they in some cases unrelated to clinical outcome? Quantitative experimental studies on the basic biology of metastatic inefficiency are providing clues that may help in understanding the significance of these cells. This understanding will be of use in guiding clinical studies to assess the significance of isolated tumour cells and micrometastases in cancer patients.