Synaptic inputs to the ganglion cells in the tiger salamander retina.
Synaptic inputs to the ganglion cells in the tiger salamander retina.
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DOI：
10.1085/jgp.73.3.265
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发表时间：
1979-03
期刊：
影响因子：
--
通讯作者：
Werblin FS
中科院分区：
文献类型：
--
作者：
Wunk DF;Werblin FS
形成神经节细胞光反应的突触后电位（PSP）通过在细胞感受野的中心或周围刺激时用外源性电流极化细胞膜来分离。PSP的时程和感受野特性与双极细胞和无长突细胞的时程和感受野特性相关。虎蝾螈视网膜包含四种主要类型的神经节细胞：“on”中心，“off”中心，“on-off”和“hybrid”细胞，其对中心的反应短暂，但对周围照明的反应持续。结果导致这些推论。神经节上的细胞接受来自双极神经元的兴奋性突触输入，并且该突触在黑暗中是“沉默的”。关闭的神经节细胞从关闭的双极接收兴奋性突触输入，该突触在黑暗中具有紧张性活性。开关型和混合型神经节细胞接受的是一种感受野较窄的瞬时兴奋性输入，而不是简单地与任何一个突触前细胞的活动相关。所有类型的细胞都接受宽场瞬时抑制性输入，这显然起源于瞬时无长突细胞。因此，大多数，但不是所有的，神经节细胞的反应可以解释在双极和无长突细胞的突触输入，在神经节细胞膜集成。
The postsynaptic potentials (PSPs) that form the ganglion cell light response were isolated by polarizing the cell membrane with extrinsic currents while stimulating at either the center or surround of the cell's receptive field. The time-course and receptive field properties of the PSPs were correlated with those of the bipolar and amacrine cells. The tiger salamander retina contains four main types of ganglion cell: "on" center, "off" center, "on-off", and a "hybrid" cell that responds transiently to center, but sustainedly, to surround illumination. The results lead to these inferences. The on-ganglion cell receives excitatory synpatic input from the on bipolars and that synapse is "silent" in the dark. The off-ganglion cell receives excitatory synaptic input from the off bipolars with this synapse tonically active in the dark. The on-off and hybrid ganglion cells receive a transient excitatory input with narrow receptive field, not simply correlated with the activity of any presynaptic cell. All cell types receive a broad field transient inhibitory input, which apparently originates in the transient amacrine cells. Thus, most, but not all, ganglion cell responses can be explained in terms of synaptic inputs from bipolar and amacrine cells, integrated at the ganglion cell membrane.