Nuclear positioning in migrating fibroblasts.
Nuclear positioning in migrating fibroblasts.
复制标题
迁移成纤维细胞中的核定位。
DOI：
10.1016/j.semcdb.2017.11.006
复制
发表时间：
2018
影响因子：
7.3
通讯作者：
Gundersen,GreggG
中科院分区：
文献类型：
--
作者：
Zhu,Ruijun;Liu,Chenshu;Gundersen,GreggG
细胞核的定位和运动最近已成为细胞迁移的一个重要方面。在成纤维细胞迁移的研究中，对细胞核定位和运动的理解已经达到了顶峰。特定的核定位和运动已被描述成纤维细胞的极化细胞迁移和在2D和3D环境中的主动迁移。在这里，我们回顾了最近的研究，发现了新的分子机制，有助于这些事件在成纤维细胞。其中许多涉及通过由外核膜nesprin和内核膜SUN蛋白组成的LINC复合物连接细胞核和细胞骨架。我们认为，适当的核定位有助于有效的成纤维细胞极化和迁移和细胞核影响细胞迁移的可能机制的证据。
The positioning and movement of the nucleus has recently emerged as an important aspect of cell migration. Understanding of nuclear positioning and movement has reached an apogee in studies of fibroblast migration. Specific nuclear positioning and movements have been described in the polarization of fibroblast for cell migration and in active migration in 2D and 3D environments. Here, we review recent studies that have uncovered novel molecular mechanisms that contribute to these events in fibroblasts. Many of these involve a connection between the nucleus and the cytoskeleton through the LINC complex composed of outer nuclear membrane nesprins and inner nuclear membrane SUN proteins. We consider evidence that appropriate nuclear positioning contributes to efficient fibroblast polarization and migration and the possible mechanism through which the nucleus affects cell migration.