Tissue plasminogen activator and seizures: a clot-buster's secret life.
Tissue plasminogen activator and seizures: a clot-buster's secret life.
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组织纤溶酶原激活剂和癫痫发作：血栓破坏者的秘密生活。
DOI：
10.1172/jci15961
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Strickland,Sidney
中科院分区：
文献类型：
--
作者：
Pawlak,Robert;Strickland,Sidney
癫痫是由超同步电活动引起的，当大脑的某个区域因各种病理原因(如退行性疾病、脑瘤或头部创伤)而受损时，就会发生癫痫发作。癫痫是一个极其普遍的问题，大约10%的人口一生中至少经历过一次。它们是危险的，既因为它们产生的运动活动不受控制，也因为它们可以导致神经元死亡，在某些情况下还会导致永久性的神经缺陷(1)。苯妥英钠和相关的抗癫痫药通过延长动作电位的不应期起作用。这种延伸阻止了神经元进入与癫痫发作相关的快速放电，但允许正常的传导发生。这些药物的治疗范围通常很窄，即使在剂量优化的情况下，也往往会产生不良的副作用。
Seizures, caused by hypersynchronized electrical activity, can occur when an area of the brain becomes injured as a result of various pathologies such as degenerative disorders, brain tumors, or head trauma. Seizures are an extremely widespread problem, with about 10% of the population experiencing them at least once in their lives. They are hazardous both because of the uncontrolled motor activity they generate and because they can cause neuronal death and in some cases permanent neurological deficits (1). Phenytoin and related antiseizure agents act by prolonging the refractory period of the action potential. This extension prevents the neurons from entering into the rapid firing associated with seizures but allows normal conduction to occur. These drugs generally have a narrow therapeutic range and often have undesirable side effects even when the dosage is optimized.