ANCIENT URBANIZATION PREDICTS GENETIC RESISTANCE TO TUBERCULOSIS
ANCIENT URBANIZATION PREDICTS GENETIC RESISTANCE TO TUBERCULOSIS
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DOI：
10.1111/j.1558-5646.2010.01132.x
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发表时间：
2011-03-01
期刊：
影响因子：
3.3
通讯作者：
Thomas, Mark G.
中科院分区：
文献类型：
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作者：
Barnes, Ian;Duda, Anna;Thomas, Mark G.
城市生活和疾病之间的联系在最近的历史记录中被发现，但这种联系在史前的存在很难评估。如果向城市生活的过渡确实导致了疾病死亡率的增加，我们可能会看到长期城市化人口的抗病能力增强的证据，这是自然选择的结果。为了验证这一点，我们确定了与对细胞内病原体如结核病和麻风病的天然抗性相关的等位基因（SLC11A11729 + 55del4）的频率。我们发现了一个高度显着的相关性与城市定居的时间，在城镇生活的历史较长的人口更好地适应抵抗这些感染。这种相关性仍然很强，当我们校正等位基因频率的自相关性，由于共享的人口历史。因此，我们的研究结果支持了这样的解释，即传染病负荷在城市化到来后成为人类死亡率越来越重要的原因，突出了人口密度在决定人类健康和人类群体遗传结构方面的重要性。
A link between urban living and disease is seen in recent and historical records, but the presence of this association in prehistory has been difficult to assess. If the transition to urban living does result in an increase in disease-based mortality, we might expect to see evidence of increased disease resistance in longer-term urbanized populations, as the result of natural selection. To test this, we determined the frequency of an allele (SLC11A1 1729 + 55del4) associated with natural resistance to intracellular pathogens such as tuberculosis and leprosy. We found a highly significantly correlation with duration of urban settlement-populations with a long history of living in towns are better adapted to resisting these infections. This correlation remains strong when we correct for autocorrelation in allele frequencies due to shared population history. Our results therefore support the interpretation that infectious disease loads became an increasingly important cause of human mortality after the advent of urbanization, highlighting the importance of population density in determining human health and the genetic structure of human populations.