Neutrophil extracellular traps kill bacteria
Neutrophil extracellular traps kill bacteria
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DOI：
10.1126/science.1092385
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发表时间：
2004-03-05
期刊：
影响因子：
56.9
通讯作者：
Zychlinsky, A
中科院分区：
文献类型：
--
作者：
Brinkmann, V;Reichard, U;Zychlinsky, A
当中性粒细胞的抗菌颗粒与吞噬小体融合时，它们会吞噬并杀死细菌。在这里，我们描述了中性粒细胞在激活后释放颗粒蛋白和染色质，它们共同形成结合革兰氏阳性和阴性细菌的细胞外纤维。这些中性粒细胞胞外陷阱(Net)降解毒力因子并杀死细菌。在实验性痢疾和自发性人类阑尾炎这两个急性炎症的例子中，体内存在大量的Net。蚊帐似乎是一种天生的反应，可以结合微生物，防止它们传播，并确保局部高浓度的抗菌剂，以降低毒力因子和杀死细菌。
Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill bacteria. NETs are abundant in vivo in experimental dysentery and spontaneous human appendicitis, two examples of acute inflammation. NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria.