Efficient Protocol for the Phosphine-Free Suzuki-Miyaura Reaction Catalyzed by Palladium on Carbon at Room Temperature
Efficient Protocol for the Phosphine-Free Suzuki-Miyaura Reaction Catalyzed by Palladium on Carbon at Room Temperature
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室温下钯碳催化的无磷 Suzuki-Miyaura 反应的高效方案
DOI：
10.1055/s-2005-861880
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Guolin Zhang
中科院分区：
文献类型：
--
作者：
Guolin Zhang
利用商用的10%Pd/C(3.5mol%Pd)在乙醇-水(1：1)和Na2CO3中于室温下进行芳基溴化物和芳基硼酸的无膦Suzuki-Miyaura偶联反应，建立了一种温和而有效的方法。该反应方便，环境友好，偶联产物的产率很高(94-100%)。催化剂可以通过简单的过滤和洗涤程序进行回收，直到第四次偶联产物的产率都不会有明显的下降。
A mild and efficient protocol for the phosphine-free Suzuki-Miyaura coupling reaction of aryl bromides with arylboronic acids has been developed which utilizes the commercially available 10% Pd/C (3.5 mol% Pd) in ethanol-water (1:1) and Na 2 CO 3 at room temperature. The reaction is convenient, environmentally benign and generates excellent yields of the coupled products (94-100%). The catalyst can be recycled using simple filtration and washing sequences without significant decrease in the yield of coupling product up to the fourth run.