Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin.
Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin.
复制标题
与丰加霉素和桑吉瓦霉素相关的某些 7-[(2-羟基乙氧基)甲基]吡咯并[2,3-d]嘧啶核苷的合成、细胞毒性和抗病毒活性。
DOI：
10.1021/jm00127a003
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发表时间：
1989
影响因子：
7.3
通讯作者：
Townsend,LB
中科院分区：
文献类型：
--
作者：
Gupta,PK;Nassiri,MR;Coleman,LA;Wotring,LL;Drach,JC;Townsend,LB
12，X-CONHNH2转化为RNA。虽然掺入可以产生对RNA病毒的选择性抗病毒活性，但我们发现托伊霉素对疱疹病毒的活性与其在未感染细胞中的细胞毒性几乎没有差异。这些结果使我们得出结论，这些核糖化合物没有作为抗疱疹药物的潜力。13相比之下，无环核苷如无环病毒14“16是一类重要的化合物，具有广泛的抗病毒特性。
12, X-CONHNH2 into RNA. lla Although incorporation may produce se-lective antiviral activity for RNA viruses, we have found little or no differential between the activity of toyocamycin against herpes viruses and its cytotoxicity in uninfected cells. These results led us to conclude that these ribosyl compounds do not have potential as anti-herpes agents. 13 In contrast, acyclonucleosides such as acyclovir14" 16 are an important class of compounds having a broad range of antiviral properties. Intensive efforts to develop other acyclic nucleoside17" 20 analogues have producedganciclovir