Marked Seizure Reduction after MCT Supplementation
Marked Seizure Reduction after MCT Supplementation
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DOI：
10.1155/2013/809151
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发表时间：
2013-01-01
影响因子：
0.9
通讯作者：
Azar, Nabil J.
中科院分区：
文献类型：
--
作者：
Azzam, Raed;Azar, Nabil J.
我们报告的情况下，一个43岁的男子与历史的非手术部分癫痫谁以前失败的抗癫痫药物的多次试验。中链甘油三酯（MCT）以纯油的形式添加到他的常规饮食中。随后，他的癫痫发作频率从每天多次癫痫发作显著降低到每四天一次。他的癫痫发作在MCT短暂停药10天后复发。他的癫痫发作改善是在每天两次服用四汤匙MCT的剂量下实现的，没有报告副作用。他在较高剂量下出现了严重腹泻和肠胃气胀。我们得出结论，MCT油补充到常规饮食中可能会为某些患者提供更好的癫痫控制。MCT油补充剂可能是标准生酮饮食更耐受的替代方案。
We report the case of a 43-year-old man with history of nonsurgical partial epilepsy who previously failed multiple trials of antiepileptic drugs. Medium-chain triglycerides (MCT) were added to his regular diet in the form of pure oil. Subsequently, his seizure frequency was markedly reduced from multiple daily seizures to one seizure every four days. His seizures recurred after transient discontinuation of MCT over a period of ten days. His seizure improvement was achieved at a dose of four tablespoons of MCT twice daily with no reported side effects. He developed significant diarrhea and flatulence at higher doses. We conclude that MCT oil supplementation to regular diet may provide better seizure control in some patients. MCT oil supplementation may be a more tolerable alternative to the standard ketogenic diet.