Differentiation of the mammary gland and susceptibility to carcinogenesis.
Differentiation of the mammary gland and susceptibility to carcinogenesis.
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DOI：
10.1007/bf01805718
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发表时间：
1982-01-01
影响因子：
3.8
通讯作者：
Russo, I H
中科院分区：
文献类型：
--
作者：
Russo, J;Tay, L K;Russo, I H
已经证明，在人类中，某些因素，如月经初潮早、怀孕晚和未生育，与患乳腺癌的风险更高有关，而早孕则是一种保护因素。通过给予化学致癌剂7，12-二甲基苯(A)菲诱发大鼠乳腺癌表明，影响人类乳腺癌风险的相同因素也影响大鼠乳腺对化学致癌物的敏感性。未分娩的大鼠和终止妊娠的大鼠更容易患癌症。这一事实被归因于在给予致癌物时腺体分化不完全。分娩的大鼠对DMBA的致癌作用具有抵抗力，这是由于怀孕和哺乳期间腺体完全发育所致。这种发育表现为顶芽分化为分泌单位，分泌单位具有较小的增殖间隔；这些分泌单位的上皮细胞具有较长的细胞周期，对DMBA结合的亲和力较低，并具有更有效的DNA切除修复能力。
It has been demonstrated that in humans certain factors such as early menarche, late pregnancy, and nulliparity are associated with a higher risk of developing breast cancer, while early pregnancy acts as a protective factor. Induction of mammary cancer in rats by administration of the chemical carcinogen 7,12-dimethylbenz(a)anthracene reveals that the same factors influencing human breast cancer risk also affect the susceptibility of the rat mammary gland to the chemical carcinogen. Nulliparous rats and rats undergoing pregnancy interruption are more susceptible to developing carcinomas. This fact has been attributed to the incomplete differentiation of the gland at the time of carcinogen administration. Parous rats are resistant to the carcinogenic effect of DMBA, which is explained by the complete development of the gland attained during pregnancy and lactation. This development is manifested by the differentiation of terminal end buds into secretory units, which have a smaller proliferative compartment; the epithelial cells of these secretory units have a longer cell cycle, less avidity for binding DMBA, and possess a more efficient DNA excision repair capacity.