Soluble mesothelin-related protein - A blood test for mesothelioma
Soluble mesothelin-related protein - A blood test for mesothelioma
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DOI：
10.1016/j.lungcan.2005.03.020
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发表时间：
2005-07-01
期刊：
影响因子：
5.3
通讯作者：
Hellstrom, I
中科院分区：
文献类型：
--
作者：
Robinson, BWS;Creaney, J;Hellstrom, I
间皮瘤（MM）的肿瘤标志物的鉴定可能被证明是有用的诊断，以及监测肿瘤对治疗的反应和筛查高危个体。我们测试了血清中的可溶性间皮素相关蛋白（SMRP）（间皮素家族成员）将是这种标志物的假设。我们的数据表明，在前48例MM患者中，血清SMRP的测定是MM的标志物，灵敏度为83%，特异性为95%。血清SMRP水平的变化与临床病程/肿瘤大小平行，75%的患者在诊断时SMRP升高。SMRP也应该是有用的监测疾病的进展，重要的是，可能证明有用的筛选石棉暴露的个人早期MM。皇冠版权所有（c）2005年出版的爱思唯尔爱尔兰有限公司保留所有权利。
Identification of tumor marker for mesothelioma (MM) might prove useful in diagnosis as well as for monitoring tumor in response to therapy and for screening at-risk individuals. We tested the hypothesis that soluble mesothelin-related protein (SMRP), a mesothelin family member, in the serum would be such a marker. Our data show that determination of SMRP in serum is a marker of MM with a sensitivity of sensitivity 83% and specificity 95% in the first 48 MM patients tested. Changes in serum SMRP levels parallel clinical course/tumor size and SMRP is elevated in 75% of patients at diagnosis. SMRP should also be useful for monitoring disease progression, and importantly, may prove useful for screening asbestos-exposed individuals for early MM. Crown Copyright (c) 2005 Published by Elsevier Ireland Ltd. All rights reserved.