Phylogeography of Chinese house mice (Mus musculus musculus/castaneus): distribution, routes of colonization and geographic regions of hybridization
Phylogeography of Chinese house mice (Mus musculus musculus/castaneus): distribution, routes of colonization and geographic regions of hybridization
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中国家鼠（Mus musculus musculus/castaneus）的系统发育地理学：分布、定植途径和杂交地理区域
DOI：
10.1111/mec.12873
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发表时间：
2014-09-01
影响因子：
4.9
通讯作者：
Huang, Ling
中科院分区：
文献类型：
--
作者：
Jing, Meidong;Yu, Hon-Tsen;Huang, Ling
家鼠（Mus musculus）是人类的动物，是生物医学、生态学和进化研究的主要模型。虽然欧洲有详细的家鼠地理学知识，但对中国家鼠的历史却知之甚少，尽管中国涵盖了家鼠分布的很大一部分。本研究对中国29个地区的535只家鼠进行了线粒体D-loop序列测定和分布于10条染色体上的10个核微卫星标记的基因分型。系统发育分析显示，以长江为界，南方和北方分别对应于小家鼠（Mus musculus castaneus）和小家鼠（Mus musculus musculus）。更详细的分析结合了从邻国采样的小鼠的已发表序列数据，揭示了两个亚种进入中国的迁移路线：M。M. castaneus似乎是通过南方路线（云南和广西）迁移的，而M. M.小家鼠从哈萨克斯坦通过西北边境（新疆）进入中国。对线粒体序列的贝叶斯分析表明，这两个亚种的人口迅速扩张，大约在4650-9300年和7150- 14300年前。M. castaneus和M. M.肌肉，分别。有趣的是，中国家鼠的迁徙路线与现代人类进入中国的殖民路线相吻合，家鼠的扩张时间分别与中国南方和北方农业的发展相吻合。最后，我们的研究证实了M. M. castaneus和M. M. musculus在中国。对这一混合带的进一步研究将为M. M.欧洲中部的小家鼠和小家鼠。
House mice (Mus musculus) are human commensals and have served as a primary model in biomedical, ecological and evolutionary research. Although there is detailed knowledge of the biogeography of house mice in Europe, little is known of the history of house mice in China, despite the fact that China encompasses an enormous portion of their range. In the present study, 535 house mice caught from 29 localities in China were studied by sequencing the mitochondrial D‐loop and genotyping 10 nuclear microsatellite markers distributed on 10 chromosomes. Phylogenetic analyses revealed two evolutionary lineages corresponding to Mus musculus castaneus and Mus musculus musculus in the south and north, respectively, with the Yangtze River approximately representing the boundary. More detailed analyses combining published sequence data from mice sampled in neighbouring countries revealed the migration routes of the two subspecies into China: M. m. castaneus appeared to have migrated through a southern route (Yunnan and Guangxi), whereas M. m. musculus entered China from Kazakhstan through the north‐west border (Xinjiang). Bayesian analysis of mitochondrial sequences indicated rapid population expansions in both subspecies, approximately 4650–9300 and 7150–14 300 years ago for M. m. castaneus and M. m. musculus, respectively. Interestingly, the migration routes of Chinese house mice coincide with the colonization routes of modern humans into China, and the expansion times of house mice are consistent with the development of agriculture in southern and northern China, respectively. Finally, our study confirmed the existence of a hybrid zone between M. m. castaneus and M. m. musculus in China. Further study of this hybrid zone will provide a useful counterpart to the well‐studied hybrid zone between M. m. musculus and Mus musculus domesticus in central Europe.