ODORTYPES DETERMINED BY THE MAJOR HISTOCOMPATIBILITY COMPLEX IN GERM-FREE MICE
ODORTYPES DETERMINED BY THE MAJOR HISTOCOMPATIBILITY COMPLEX IN GERM-FREE MICE
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DOI：
10.1073/pnas.87.21.8413
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发表时间：
1990-11-01
影响因子：
11.1
通讯作者：
BOYSE, EA
中科院分区：
文献类型：
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作者：
YAMAZAKI, K;BEAUCHAMP, GK;BOYSE, EA
主要组织相容性复合体（MHC）是主要的，但不是唯一的决定基因特异性组成的身体气味，称为气味型，强烈代表在尿液中的小鼠。MHC决定的气味类型的感知影响生殖行为的情况下，配偶的选择和维护早孕，倾向于有利于一个MHC类型的传播。MHC基因型如何决定MHC气味类型尚不清楚。一种可能的解释是，不同的气味是由微生物的组成以某种方式适应MHC多样性的群体产生的。这一假设在Y-迷宫系统中进行了测试，在该系统中，小鼠被训练来区分MHC同源小鼠的尿液气味。首先，研究表明，小鼠可以很容易地被训练来区分无菌MHC同源小鼠的尿液。第二，研究表明，经过训练的小鼠可以区分常规维持的MHC同源小鼠的尿液，也可以很容易地区分无菌MHC同源小鼠的尿液。这些结果意味着MHC确定的气味类型不依赖于气味产生的戈伊微生物。
The major histocompatibility complex (MHC) is the prime but not exclusive determinant of genetically specific constitutive body odors, termed odortypes, represented strongly in urine of the mouse. Perception of MHC-determined odortypes influences reproductive behavior in the contexts of mate choice and maintenance of early pregnancy, tending to favor the propagation of one MHC type over another. How MHC genotype determines MHC odortype is unknown. One possible explanation is that differential odorants are generated by populations of commensal microorganisms whose composition is somehow geared to MHC diversity. This hypothesis was tested in the Y-maze system in which mice are trained to distinguish the urinary odors of MHC-congenic mice. First, it was shown that mice could readily be trained to distinguish the urines of germfree MHC-congenic mice. Second, it was shown that mice trained to distinguish the urines of conventionally maintained MHC-congenic mice could as readily distinguish the urines of germfree MHC-congenic mice. These results imply that MHC-determined odortypes do not depend on odorants generated gy microorganisms.