Association of Environmental Toxic Elements in Biological Samples of Myocardial Infarction Patients at Different Stages
Association of Environmental Toxic Elements in Biological Samples of Myocardial Infarction Patients at Different Stages
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DOI：
10.1007/s12011-010-8713-2
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发表时间：
2011-06-01
影响因子：
3.9
通讯作者：
Kolachi, Nida Fatima
中科院分区：
文献类型：
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作者：
Afridi, Hassan Imran;Kazi, Tasneem Gul;Kolachi, Nida Fatima
有毒元素的暴露可能与心脏病的不同发病机制直接或间接相关。本研究对心肌梗死（MI）患者在第一次、第二次和第三次心脏病发作时的生物样本（全血和尿）中砷（As）、镉（Cd）、钴（Co）、铅（Pb）和镍（Ni）与死亡率的关系进行了研究。收集年龄在45 ~ 60岁之间的心肌梗死患者130例（男性77例，女性53例）和同一年龄段的健康人群61例（男性33例，女性28例）的生物学样本。用电热原子吸收分光光度计测定生物样品中的元素，然后用微波辅助酸消化。用生物标准品验证了方法的有效性。在本研究中，32例50岁以上的患者，在第三次心肌梗死发作后登记，78%死亡。其中，心肌梗死患者血中As、Cd、Co、Ni、Pb含量较对照者高（p < 0.05），而耐受心肌梗死第三次发作患者血中As、Cd、Co、Ni、Pb含量分别比对照者高11.7%、12.2%、5.55%、7.2% （p = 0.12）。高水平的未充分研究的有毒元素可能在心肌梗死患者的死亡率中发挥作用。
The exposure of toxic elements may directly or indirectly associate with different pathogenesis of heart diseases. In the present study, the association of arsenic (As), cadmium (Cd), cobalt (Co), lead (Pb), and nickel (Ni) in biological samples (whole blood and urine) and mortality from myocardial infarction (MI) patients at first, second, and third heart attacks was carried out. Both biological samples of 130 MI patients (77 male and 53 female), with ages ranging from 45 to 60 years, and 61 healthy persons (33 male and 28 female) of the same age group were collected. The elements in biological samples were assessed by electrothermal atomic absorption spectrophotometer, prior to microwave-assisted acid digestion. The validity of methodology was checked by the biological certified reference materials. During this study, 78% of 32 patients aged above 50 years, registered after third MI attack, died. In these subjects, the levels of As, Cd, Co, Ni, and Pb in blood samples were higher in MI patients as compared with referents (p < 0.05), while increased by 11.7%, 12.2%, 5.55%, and 7.2%, respectively, in the blood samples of those patients who tolerated the third MI attack (p = 0.12). The high level of understudied toxic elements may play a role in the mortality of MI patients.