QUANTITATIVE ROTATIONAL TL-201 TOMOGRAPHY FOR IDENTIFYING AND LOCALIZING CORONARY-ARTERY DISEASE
QUANTITATIVE ROTATIONAL TL-201 TOMOGRAPHY FOR IDENTIFYING AND LOCALIZING CORONARY-ARTERY DISEASE
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用于识别和定位冠状动脉疾病的定量旋转 TL-201 层析成像技术
DOI：
10.1161/01.cir.77.2.316
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发表时间：
1988-02-01
期刊：
影响因子：
37.8
通讯作者：
BERGER, HJ
中科院分区：
文献类型：
--
作者：
DEPASQUALE, EE;NODY, AC;BERGER, HJ
本研究的目的是开发和验证一种方法，用于量化的摄取，再分布，和洗出的铊-201（201 Tl）获得旋转断层扫描。该方法生成左心室短轴切片的最大计数圆周轮廓，将其转换为极坐标轮廓并将其显示为靶心图，该靶心图由一系列同心圆组成，顶点在中心，底部在外围。在36例狭窄程度较低的患者（直径狭窄<50%和31例< 50%）中确定了201 Tl分布的正常范围。比较了视觉、定量以及视觉和定量结合分析对疾病的总体检测和对单个血管受累的检测。通过这些方法检测疾病的总体灵敏度分别为97%、95%和95%。特异性分别为68%、74%和71%。单用牛眼检测单个血管受累的灵敏度为左前降支（LAD）78%，右冠状动脉（RCA）89%，左回旋支（LCx）65%。对于视觉分析，结果分别为70%、88%和50%，而视觉和定量分析的结合使用识别了75%的LAD、87%的RCA和55%的LCx病变。我们的结论是，定量分析旋转201 Tl断层图像是一种高度准确的技术，用于确定CAD的存在和位置。
The purpose of this study was to develop and validate a method for quantifying the uptake, redistribution, and washout of thallium-201 (201Tl) obtained with rotational tomography. This method generates maximum count circumferential profiles of the short-axis slices of the left ventricle, translates them into polar coordinate profiles and displays them as a bullseye plot, which consists of a series of concentric circles with the apex at the centre and the base at the periphery. Normal limits was established for the distribution of 201Tl in 36 patients with a low (50% diameter stenosis and 31 with < 50%). Visual, quantitative, and combined visual and quantitative analysis were compared for overall detection of disease and for detection of individual vessel involvement. The overall sensitivity for detection of disease by these methods was 97%, 95%, and 95%, respectively. The specificities were 68%, 74%, and 71% respectively. The sensitivity for detection of individual vessel involvement with the bullseye alone was 78% for the left anterior descending artery (LAD) 89% for the right coronary artery (RCA), and 65% for the left circumflex (LCx). For visual analysis, the results were 70%, 88%, and 50%, respectively, while the use of visual and quantitative analysis combined identified 75% of LAD, 87% of RCA, and 55% of LCx lesions. We conclude that quantitative analysis of rotational 201Tl tomographic images is a highly accurate technique for determining the presence and location of CAD.