Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
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DOI：
10.1038/ng.148
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发表时间：
2008-06-01
期刊：
影响因子：
30.8
通讯作者：
Schreiber, Stefan
中科院分区：
文献类型：
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作者：
Franke, Andre;Balschun, Tobias;Schreiber, Stefan
在对克罗恩病近期的全基因组关联研究（GWAS）进行后续研究时，我们在德国的一个样本中对50个先前报道的易感位点进行了研究，该样本包括克罗恩病患者（n = 1850）、溃疡性结肠炎患者（n = 1103）以及健康对照者（n = 1817）。在这些位点中，我们确定3p21.31、NKX2 - 3和CCNY中的变异是这两种疾病的易感因素，而在我们的样本集合中，PTPN2、HERC2和STAT3中的变异仅与溃疡性结肠炎相关。
Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.